ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Longitudinal blood pressure trajectories and tau-lipid biomarkers associated with dementia in hypertensive adults: Results from the population-based CRHCP cohort.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionBlood pressure (BP) trajectories are associated with dementia, but their relevance across neurodegenerative and metabolic backgrounds in hypertensive populations remains unclear.
methodsWe analyzed 28,135 hypertensive participants from the China Rural Hypertension Control Project to estimate BP trajectories over 4 years using latent class group-based models. A nested case-control study was designed to assess interaction effects between BP trajectories and pTau217-lipid composite indices on dementia.
resultsFour BP trajectories were identified. In fully adjusted models, the high-stable diastolic BP trajectory showed the strongest association with dementia (odds ratio [OR] = 2.14, 95% confidence interval [CI] 1.74-2.63), followed by high-stable systolic BP trajectory (OR = 1.75, 95% CI 1.42-2.15). In the nested case-control analysis, significant interactions between pTau217-lipid composite indices and BP trajectories (high-declining and moderate-stable) were observed in relation to dementia. DISCUSSION: High-stable BP trajectories were consistently associated with dementia, whereas the associations between high-declining and moderate-stable BP trajectories varied according to pTau217-lipid composite indices.
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