ArticleJournal of Korean medical science2026
Incidence of Metabolic Dysfunction-Associated Steatotic Liver Disease After Developing Depression: A Population-Based Cohort Study.
Article in Journal of Korean medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A cardiometabolic risk phenotype index integrating insulin resistance, systemic inflammation, and psychological burden for mortality risk stratification in metabolic dysfunction-associated steatotic liver disease: an exploratory longitudinal analysis of a nationally representative cohort.Lipids in health and disease · 2026Article
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10 authors.
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Abstract
backgroundAs a significant public health issue, research on metabolic dysfunction-associated steatotic liver disease (MASLD) has increased; however, studies exploring the relationship between MASLD and depression are scarce. Thus, our objective was to examine the impact of depression on the subsequent risk of developing MASLD in a large cohort of Korean adults and to investigate the stratification of this association by sex and menopausal status.
methodsWe utilized a large-scale, population-based cohort study in South Korea, specifically the Kangbuk Samsung Health Study. Hepatic steatosis was diagnosed using ultrasonography. Depressive symptoms were assessed by the Center for Epidemiologic Studies-Depression (CES-D) score, and participants were categorized into no-depression (CES-D < 8, reference), sub-threshold depression (CES-D: 8-15), and depression (CES-D ≥ 16). Cox proportional hazards models were used to estimate the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Several interaction and stratification analyses were performed based on sex, age, and menopausal status.
resultsDuring the 1,016,691.99 person-years of follow-up, 170,981 Korean adults (men, 71,796 [42.0%]; women, 99,185 [58.0%]) were followed for a median of 5.4 years (maximum, 12.9 years). In total, 41,932 (24.5%) individuals with incident MASLD were identified. Compared with CES-D < 8, the aHRs (95% CIs) for incident MASLD were 1.03 (1.00-1.06;
conclusionDepression was associated with an increased risk of MASLD in both sexes and acted as a potential independent risk factor, particularly in women aged < 45. These findings suggest that screening for MASLD should be considered in younger women with depression.
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