ArticleInfection & chemotherapy2026
Genetic Insights into Colistin Resistance in Carbapenem-Resistant
Article in Infection & chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
Funding
Abstract
backgroundColistin is a last-resort antibiotic for treating carbapenem-resistant MATERIALS AND
methodsAntimicrobial susceptibility testing was performed using broth microdilution, and whole-genome sequencing was employed to identify acquired antimicrobial resistance genes, mutations associated with colistin resistance, virulence-associated genes (VAGs), and plasmid replicons.
resultsAll isolates were multidrug-resistant but remained susceptible to amikacin and, in 80% of cases, tigecycline. Multilocus sequence typing revealed 6 distinct sequence types with ST16 predominating. Average nucleotide identity and core genome single-nucleotide polymorphism analysis suggested clonal relatedness. While no
conclusionOur findings highlight the convergence of resistance and virulence in clonally related CRKP strains, emphasizing the need for continued genomic surveillance and antimicrobial stewardship.
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