ArticleMedical and veterinary entomology2026
Insecticidal and immunotoxic actions of 2-octenoic acid in the green bottle fly Lucilia sericata (Diptera: Calliphoridae).
Article in Medical and veterinary entomology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Insecticidal and immunotoxic actions of 2-octenoic acid in the green bottle fly Lucilia sericata (Diptera: Calliphoridae).Medical and veterinary entomology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The blow fly Lucilia sericata is a medically and veterinary important species whose control increasingly requires environmentally safe alternatives to synthetic insecticides. This study evaluated the effects of 2-octenoic acid (C8:1), a medium-chain unsaturated fatty acid, on the survival, development and physiological integrity of L. sericata larvae and adults. Topical application of C8:1 caused significant mortality and developmental delays in a dose-dependent manner, with LD50 and LD100 values indicating greater susceptibility in larvae than in adults. Cuticular lipid profiling revealed profound alterations in free fatty acid (FFA) and sterol composition following treatment. Larvae exhibited progressive accumulation of medium- and long-chain FFAs (notably C16:0, C18:0 and C14:1) and depletion of cholesterol, suggesting weakened barrier integrity. In adults, sublethal exposure (LD50) resulted in marked lipid enrichment and incorporation of exogenous C8:1, followed by almost complete depletion of FFAs and cholesterol at lethal doses (LD100), reflecting metabolic collapse. Ethanol (solvent) treatment had minor effects compared with the strong lipid disruptions caused by C8:1. Haemocyte analyses demonstrated dose-dependent immunotoxicity, including granulocyte depletion, cytoplasmic shrinkage and increased proportions of plasmatocytes and oenocytoids, indicating impaired phagocytic and encapsulation responses. These combined effects-cuticular lipid disorganization, cholesterol depletion and haemocyte damage-suggest that 2-octenoic acid compromises both physical and immune defenses. The findings identify 2-octenoic acid as a promising bio-based insecticidal compound with multiple, non-neurotoxic modes of action, offering potential for integrated management of blow fly infestations while reducing risks associated with conventional insecticides.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.