Evidence map›Paper›PMID 41943138›Full record

ArticleJournal of nanobiotechnology2026

Targeted hyperthermia therapy (THT) using gold nanorods remodels the tumor microenvironment to sensitize murine microsatellite-stable colorectal cancer to immune checkpoint blockade.

Barry E Kennedy, Julie L Jordan, Geetha Subramanian, Kate N Clark, Cheryl Dean, Nicholas P Cheverie, Kelly J Corscadden, Caitlin Gormley, Erin B Noftall, Mark R Hanes and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Barry E KennedyDepartment of Pathology, Dalhousie University, Halifax, Canada.
Julie L JordanDepartment of Pathology, Dalhousie University, Halifax, Canada.
Geetha SubramanianDepartment of Pathology, Dalhousie University, Halifax, Canada.
Kate N ClarkDepartment of Pathology, Dalhousie University, Halifax, Canada.
Cheryl DeanDepartment of Pathology, Dalhousie University, Halifax, Canada.
Nicholas P CheverieDepartment of Pathology, Dalhousie University, Halifax, Canada.
Kelly J CorscaddenDepartment of Pathology, Dalhousie University, Halifax, Canada.
Caitlin GormleyDepartment of Pathology, Dalhousie University, Halifax, Canada.
Erin B NoftallDepartment of Pathology, Dalhousie University, Halifax, Canada.
Mark R HanesDepartment of Pathology, Dalhousie University, Halifax, Canada.
Alexander EdgarDepartment of Microbiology and Immunology, Dalhousie University, Halifax, Canada.
Jean S MarshallDepartment of Microbiology and Immunology, Dalhousie University, Halifax, Canada.
Carman A GiacomantonioDepartment of Pathology, Dalhousie University, Halifax, Canada. Carman.Giacomantonio@dal.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microsatellite-stable (MSS) colorectal cancers are refractory to immune checkpoint blockade (ICB) due to limited baseline inflammation, inefficient antigen presentation, and impaired T cell priming. We investigated whether nanomaterial-enabled targeted hyperthermia therapy (THT), based on intratumoral gold nanorods (GNRs) that convert near-infrared (NIR) light into localized heat, could remodel this microenvironment and enhance responsiveness to ICB. CT26 colorectal tumors were established subcutaneously in BALB/c mice. Intratumorally delivered GNRs (Sona Nanotech Inc.

Indexed as

Colorectal NeoplasmsGoldHyperthermia, InducedImmune Checkpoint InhibitorsNanotubesTumor MicroenvironmentAnimalsCell Line, TumorFemaleMiceMice, Inbred BALB CProgrammed Cell Death 1 ReceptorGoldImmune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorAntigen presentationCT26 murine modelGold nanorodsImmune checkpoint blockadeMicrosatellite-stable colorectal cancerNIR lightPD-1 resistanceTargeted hyperthermiaT cell activationTumor microenvironment

Identifiers

PMID41943138
PMCPMC13200432

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.