Evidence map›Paper›PMID 41943072›Full record

ArticleJournal of translational medicine2026

New insight about early miscarriage: a prenatal data-based study.

Yuanhang Zhu, Yaming Liu, Chunying Ren, Jing Liu, Qian Yang, Naiqi Li, Ting Wang, Ping Zhang, Jing Xue, Chenchen Ren and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yuanhang ZhuDepartment of Medical Genetics and Prenatal Diagnosis, The Third Affiliated Hospital of Zhengzhou University, No. 7, Front Kangfu Street, 450052, Zhengzhou, P.R. China.
Yaming LiuDepartment of Medical Genetics and Prenatal Diagnosis, The Third Affiliated Hospital of Zhengzhou University, No. 7, Front Kangfu Street, 450052, Zhengzhou, P.R. China.
Chunying RenDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, No. 7, Front Kangfu Street, 450052, Zhengzhou, P.R. China.
Jing LiuDepartment of Medical Genetics and Prenatal Diagnosis, The Third Affiliated Hospital of Zhengzhou University, No. 7, Front Kangfu Street, 450052, Zhengzhou, P.R. China.
Qian YangDepartment of Medical Genetics and Prenatal Diagnosis, The Third Affiliated Hospital of Zhengzhou University, No. 7, Front Kangfu Street, 450052, Zhengzhou, P.R. China.
Naiqi LiDepartment of Medical Genetics and Prenatal Diagnosis, The Third Affiliated Hospital of Zhengzhou University, No. 7, Front Kangfu Street, 450052, Zhengzhou, P.R. China.
Ting WangDepartment of Medical Genetics and Prenatal Diagnosis, The Third Affiliated Hospital of Zhengzhou University, No. 7, Front Kangfu Street, 450052, Zhengzhou, P.R. China.
Ping ZhangDepartment of Medical Genetics and Prenatal Diagnosis, The Third Affiliated Hospital of Zhengzhou University, No. 7, Front Kangfu Street, 450052, Zhengzhou, P.R. China.
Jing XueDepartment of Medical Genetics and Prenatal Diagnosis, The Third Affiliated Hospital of Zhengzhou University, No. 7, Front Kangfu Street, 450052, Zhengzhou, P.R. China.
Chenchen RenDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, No. 7, Front Kangfu Street, 450052, Zhengzhou, P.R. China. renchenchen1106@126.com.ORCID 0000-0003-3308-2447
Ling LiuDepartment of Medical Genetics and Prenatal Diagnosis, The Third Affiliated Hospital of Zhengzhou University, No. 7, Front Kangfu Street, 450052, Zhengzhou, P.R. China. 13803850510@163.com.

Funding

Henan Province Medical Science Technology Research Program Joint Construction Project LHGJ20240359the "Three 100s" Program for Overseas Training of Medical Science and Technology Talents in Henan Academy of Medical Science HNMOT2024025
6 · The paper itself

Abstract

backgroundEarly miscarriage, a common pregnancy complication predominantly occurring before 12 weeks, is conclusively linked to embryonic chromosomal abnormalities. Given the rising proportion of pregnancies at advanced maternal age, a contemporary re-examination of the relationships among early miscarriage, sex chromosomal anomalies, and maternal age is imperative to optimize clinical counseling strategies.

methodsThis retrospective study analyzed cases from the Medical Genetics and Prenatal Diagnosis Center at the Third Affiliated Hospital of Zhengzhou University (July 2022–December 2024). Inclusion criteria required fetal samples with < 10% maternal cell contamination confirmed by fluorescent PCR-capillary electrophoresis. Exclusion criteria included absence of CNV-seq/CMA testing results, discordant results, incomplete documentation, or donor oocyte pregnancies. Cases were stratified into early miscarriage (EM) group and non-EM (NEM) group. Chromosomal abnormalities (triploidy/tetraploidy, uniparental disomy and aneuploidies involving chromosomes 21, 18, 13, X, and Y), fetal sex, and maternal age were compared between groups.

resultsIn a cohort of 21,311 fetuses undergoing genetic testing, the overall prevalence of sex chromosome aneuploidies (SCAs) was 2.07%. Fetuses with EM exhibited significantly higher SCAs prevalence (7.5%) compared to NEM (1.4%, P < 0.001). Stratified analysis demonstrated elevated 45, X/mosaic 45, X frequency in EM (7.03% vs. 0.40% NEM, P < 0.001), whereas XYY/XXY/XXX/mosaic XXX was significantly lower in EM (0.34% vs. 0.97% NEM, P = 0.002). The EM rate increased with maternal age from 15 to 27 years, stabilized around 13% thereafter, and showed minor fluctuations. Maternal age was significantly lower in cases with 45,X compared to other cases (29.88 ± 4.15 vs. 31.43 ± 4.50 years, P < 0.001).

conclusionsThis observational study identified an overall SCAs prevalence of 2.07% in the cohort. Beyond sex chromosome trisomies, autosomal trisomies and 45, X demonstrated higher prevalence in the EM compared to NEM. A positive correlation existed between chromosomal trisomies prevalence and advancing maternal age, whereas 45, X exhibited inverse association with maternal aging. Distinct age-stratified pattern emerged: early miscarriage rates increased with maternal age before 27 years, stabilizing thereafter at approximately 13% without further age-dependent fluctuations.

Indexed as

Abortion, SpontaneousPrenatal DiagnosisAdultAneuploidyFemaleHumansMaternal AgePregnancySex Chromosome AberrationsAdvanced maternal ageEarly miscarriageFluorescent PCRPrenatal diagnosisSex chromosome aneuploidies

Identifiers

PMID41943072
PMCPMC13188703

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