ArticleTrials2026
Low-dose ticagrelor combined with aspirin in the prevention of early neurological deterioration of high-risk non-disabling ischemic cerebrovascular events: a PROBE clinical study.
Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundEarly neurological deterioration (END) seriously endangers the clinical prognosis of high-risk non-disabling cerebrovascular events (HR-NICE), and strong antiplatelet therapy is an effective means of preventing the occurrence of END. Studies have confirmed that ticagrelor can avoid the low efficacy of clopidogrel in antiplatelet therapy caused by CYP2C19 gene dysfunction and that its combination with aspirin can improve the clinical prognosis of patients with HR-NICE. However, the overall risk of bleeding events is relatively high. In this protocol, we compared the prevention and safety of END in patients with HR-NICE using aspirin combined with low-dose ticagrelor and aspirin combined with clopidogrel. METHODS AND ANALYSIS: This multicenter, prospective, randomised, open-label, blinded endpoints (PROBE) clinical study intended to enrol 240 patients with HR-NICE who have not undergone reperfusion therapy for block randomization. Ticagrelor combined with aspirin group (120 cases): the patients were given 120 mg of ticagrelor and 100 mg of aspirin orally on the first day of enrollment, and from the next day onwards, ticagrelor 60 mg twice daily orally and aspirin 100 mg daily orally. The clopidogrel combined with aspirin group (120 cases) was administered 300 mg clopidogrel and 100 mg aspirin orally on the first day of enrollment, and starting from the next day, 75 mg clopidogrel and 100 mg aspirin were administered orally. After 21 days, all patients were changed to aspirin 100 mg daily orally. The main efficacy outcome is the early neurological deterioration within 7 days. Safety outcomes include any bleeding events and death. DISCUSSION: This non-inferiority trial will explore whether low-dose ticagrelor combined with aspirin is superior to clopidogrel combined with aspirin for the prevention of END in patients with HR-NICE patients. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Ethics Committee of The First Affiliated Hospital of Dalian Medical University (Number Project ID PJ-KS-KY-2023-03(X)). The research results will be published as a journal article.
trial registrationChinese Clinical Trial Registry, ChiCTR2300068509. Registered on February 21, 2023. https://www.chictr.org.cn/ .
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.