Trial reportBMC oral health2026
Adjunctive effect of gaseous ozone on inflammatory biomarkers and microbial profile in grade C molar-incisor pattern periodontitis: a randomized split-mouth placebo-controlled clinical trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05971706 (Impact of Ozone Application in Periodontitis Patients), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Impact of Ozone Application in Periodontitis Patients
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5 authors.
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Abstract
backgroundThis randomized, split-mouth study aimed to evaluate the effects of adjunctive gaseous ozone therapy versus nonsurgical periodontal treatment (NSPT) alone on inflammatory cytokine levels in gingival crevicular fluid (GCF), periodontal pathogens, and clinical periodontal parameters in grade C periodontitis patients with a molar-incisor pattern (C/MIP).
methodsSeventeen (8 males and 9 females), aged 23–42 years (mean ± SD = 31.80 ± 5.26 years) systemically healthy C/MIP patients were included in the study. After NSPT was performed on all patients, topical gaseous ozone was applied to the test quadrant. This randomized split-mouth clinical trial allocated contralateral sites to test or control groups by coin toss. Clinical parameters (Plaque index, gingival index, bleeding on probing, probing depth), total GCF levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and IL-8 (analyzed via ELISA), and the presence of major periodontal pathogens including Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Tannerella forsythia (quantified by qPCR) were evaluated at baseline, 1 month, and 3 months post-treatment. Statistical analyses included both parametric (Student’s t-test, Paired Samples t-test) and non-parametric tests (Mann–Whitney U test, Wilcoxon signed-rank test, Spearman’s rank correlation test), depending on data distribution.
resultsBoth groups showed significant clinical improvement at 3 months, with no inter-group differences. However, the total amount of IL-8 in GCF levels significantly decreased after adjunctive ozone therapy (p = 0.008). A transient reduction in Prevotella intermedia was observed only in the control group. No significant microbial differences were found between groups at any time point.
conclusionsAdjunctive gaseous ozone therapy showed a significant reduction only in IL-8 levels, without additional clinical or microbiological benefits over NSPT alone in C/MIP patients.
trial registrationThe study has been registered at ClinicalTrials.gov with the registration number-first posted date: NCT05971706-2023–08-02.
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