ArticleBMC cardiovascular disorders2026
Distribution of gut microbiota and prognostic value in elderly patients with coronary atherosclerosis: a preliminary culture-based study.
Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveThis study aimed to characterize the distribution of specific cultivable gut microbiota in elderly patients with coronary artery disease (CAD) and evaluate their prognostic significance.
methodsA cohort of 200 elderly CAD patients, categorized into mild, moderate, and severe groups according to Gensini scores, together with 50 healthy elderly controls, were enrolled. Levels of specific gut microbial taxa (Bifidobacterium, Enterobacteriaceae, Lactobacillus, Enterococcus, Bacteroides) were quantified using standard anaerobic culture on selective agar media. Serum lipid profiles (TG, TC, HDL-C, LDL-C) were assessed. Correlations among microbial composition, disease severity, and lipid metabolic parameters were analyzed. Patients were followed for 6 months and stratified according to the occurrence of major adverse cardiovascular events (MACE) to assess the association between gut microbiota and clinical outcomes. Multivariable logistic regression was used to adjust for potential confounders.
resultsCompared with controls, CAD patients exhibited reduced abundances of Bifidobacterium, Lactobacillus, and Bacteroides, along with elevated levels of Enterobacteriaceae and Enterococcus. The magnitude of these changes correlated with CAD severity. These microbial alterations were significantly associated with dyslipidemia and the degree of coronary atherosclerosis. Patients with unfavorable outcomes demonstrated more pronounced alterations in these bacterial groups. After adjusting for potential confounders, the combined microbiota score remained independently associated with poor prognosis (adjusted odds ratio [OR] = 3.484, 95% CI: 2.196–5.527, P < 0.001).
conclusionElderly CAD patients display distinct alterations in the abundance of selected cultivable gut bacteria, which correlates with both disease severity and lipid metabolic status. Assessment of these bacterial groups may hold potential value for prognostic prediction in this population, but these findings require validation in larger, independent cohorts using more comprehensive sequencing-based methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.