Evidence map›Paper›PMID 41942870›Full record

ArticleBMC genomics2026

Transcriptome analysis identifies key miRNAs involved in the regulation of rabbit intramuscular fat deposition.

Guohua Song, Hui Wang, Zhuoya Jin, Qianting Duan, Ifeanyi S Ahamba, Shuhui Wang, Zhanjun Ren, Xianggui Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guohua Song *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Hui Wang *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Zhuoya Jin *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Qianting DuanKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Ifeanyi S AhambaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Shuhui WangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Zhanjun RenKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Xianggui DongKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China. xgdong@nwafu.edu.cn.

Funding

Chinese Universities Scientific Fund 2452020187Xi'an Science and Technology Plan Project 25NJSYB00008
6 · The paper itself

Abstract

backgroundIntramuscular fat (IMF) is a critical determinant of rabbit meat quality, influencing tenderness, juiciness, and flavor. miRNAs are crucial for IMF synthesis by regulating genes involved in lipid deposition, but the mechanisms by which miRNAs regulate IMF deposition in rabbits remain poorly understood. This study aimed to investigate the role of microRNAs (miRNAs) in IMF deposition in Hycole rabbits (HR) and Rex rabbits (RR) at three developmental stages (35, 75, and 150 days of age) using small RNA sequencing.

resultsA total of 195 differentially expressed (DE) miRNAs were identified in HR across the three stages, including 49 co-expressed DE miRNAs (e.g., ocu-miR-29c-5p, ocu-miR-382-3p, ocu-miR-29b-3p). In RR, 222 DE miRNAs were detected, with 45 co-expressed DE miRNAs (e.g., ocu-miR-182-5p, ocu-miR-486-5p, ocu-miR-370-5p). Comparative analysis between breeds identified 128 DE miRNAs, but none were co-expressed. GO and KEGG enrichment analyses showed DE miRNAs and their target genes were significantly enriched in pathways like PI3K-Akt, MAPK, Hippo, and HIF-1, which were closely associated with lipogenesis, metabolism, and obesity.

conclusionsThis study elucidates the transcriptional regulatory mechanisms of IMF deposition in rabbits and identifies key miRNAs influencing IMF accumulation. Our findings provide new insights into the molecular mechanisms underlying rabbit IMF deposition and offer important resources to support future genetic improvement and management strategies in rabbit production.

Indexed as

Adipose TissueGene Expression ProfilingMicroRNAsMuscle, SkeletalTranscriptomeAnimalsRabbitsMicroRNAsIntramuscular fatMeat qualitymiRNARabbitSmall RNA sequencing

Identifiers

PMID41942870
PMCPMC13188789

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