ArticleBMC genomics2026
Integrated transcriptomics, proteomics, and metabolomics analysis reveals newcastle disease virus reshapes glycerophospholipid metabolism.
Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNewcastle disease virus (NDV), a significant avian pathogen and promising oncolytic agent, relies on host metabolic pathways for replication. However, the metabolic alterations induced by NDV, particularly the connections at the gene and protein levels, remain poorly characterized.
resultsThis study employed integrated transcriptomic, proteomic, and non-targeted metabolomic analyses to delineate the global metabolic changes in NDV-infected A549 cells. We identified 8,101 differentially expressed genes (DEGs), 1,587 differentially expressed proteins (DEPs), and 257 differentially expressed metabolites (DEMs) associated with organelle function, innate immunity, and metabolism. Crucially, our multi-omics approach revealed that NDV significantly remodels glycerophospholipid metabolism. NDV depleted Lysophosphatidylcholine (LPC) and Lysophosphatidylethanolamine (LPE), as well as specific phosphatidylcholine (PC) and phosphatidylethanolamine (PE) species, while increasing phosphatidylserine (PS) at the late stage of infection. Strikingly, exogenous supplementation of unsaturated fatty acids, choline, phosphorylcholine, ethanolamine, phosphatidylethanolamine, and inositol markedly enhanced NDV replication. Concomitantly, NDV infection upregulated the transcriptional levels of key enzymes involved in glycerophospholipid biosynthesis.
conclusionsThis study demonstrates for the first time that NDV actively reprograms host glycerophospholipid metabolism to facilitate viral replication. This study uncovers a novel mechanism of NDV-host interaction and provides crucial insights for oncolytic strategies targeting this metabolic vulnerability.
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