ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2026
Residential greenness and atopic dermatitis in Japanese children: Findings from the TMM BirThree cohort study.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Association between residential greenness and preeclampsia in Japan.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Residential greenness and atopic dermatitis in Japanese children: Findings from the TMM BirThree cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
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13 authors.
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Abstract
backgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease that primarily develops during childhood. Residential greenness has been reported to be associated with AD onset. However, findings are inconsistent and may not apply to Japanese settings because vegetation and residential environments vary regionally. Therefore, this study aimed to examine early-life exposure to residential greenness and subsequent AD development in Japanese children.
methodsWe analyzed data from 14,932 children in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The exposure was residential greenness during the first 6 months of life, quantified using the normalized difference vegetation index (NDVI) within 250-, 500-, and 1000-m buffers around each birth postal code and categorized into tertiles (low [reference], moderate, high). The outcome was AD incidence between 6 months and 5 years of age, assessed via maternal reporting. Adjusted risk ratios (RRs) and 95% confidence intervals (CIs) were estimated using modified Poisson regression. Analyses were stratified by urbanization levels, child's sex, and parental history of allergic diseases.
resultsA significant protective association was observed among children in the high NDVI tertile within the 250-m buffer (adjusted RR: 0.80, 95% CI: 0.67-0.95), whereas the moderate tertile was not significant (adjusted RR: 0.94, 95% CI: 0.83-1.06). A similar pattern was observed at 500 m. Stratification showed similar associations across urbanization levels, which were stronger in boys and observed only among children without parental allergic history.
conclusionEarly-life exposure to residential greenness was associated with a decreased risk of AD in Japanese children.
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