ArticleEJNMMI radiopharmacy and chemistry2026
Radiolabeling efficiency of FENTA chelators and stability of their terbium-161, lutetium-177 and bismuth-213 complexes.
Article in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPhenanthroline derivatives are well-known chelators in coordination chemistry, but their potential in the rapidly evolving field of targeted radionuclide therapy (TRT) has not yet been explored. In TRT, DOTA remains the gold standard chelator for several clinically relevant radionuclides such as terbium-161, lutetium-177 and bismuth-213. However, its requirement for elevated labeling temperatures is a drawback, particularly for heat-sensitive targeting vectors. Although several alternative chelators have been reported in recent years, there remains an interest in new systems with suitable complexation properties. In this work, we evaluate whether phenanthroline-based ligands can serve as useful chelators in TRT, using the octadentate chelator H
resultsBF-FENTA was prepared via mono-substitution of 2,9-bis(chloromethyl)-1,10-phenanthroline with di-tert-butyl iminodiacetate, followed by a second substitution with the bifunctional arm. Both H
conclusionBoth H
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