Evidence map›Paper›PMID 41942802›Full record

ReviewJournal of the Association for Research in Otolaryngology : JARO2026

Efferent Inhibition of Hair Cells: Past, Present and Future.

Paul Albert Fuchs

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the Association for Research in Otolaryngology : JARO, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Paul Albert FuchsThe Johns Hopkins University School of Medicine, Baltimore, MD, USA. paulalbertfuchs@gmail.com.ORCID http://orcid.org/0000-0003-4627-4114

Funding

THE CHOLINERGIC RESPONSE OF COCHLEAR HAIR CELLSR01DC001508 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Amanda M. Lauer · 1992 to 2026
$13.2M
Training Program in Hearing and BalanceT32DC000023 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI CULLEN, KATHLEEN E · 1989 to 2025
$8.7M
Type II Afferents and Cochlear DamageR01DC016559 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI ELISABETH GLOWATZKI · 2017 to 2026
$4.9M
NIDCD NIH HHS R01DC001508NIDCD NIH HHS R01DC016559NIDCD NIH HHS T32DC000023
6 · The paper itself

Abstract

Efferent modulation of vertebrate auditory organs has been known since the early twentieth century, mediated by cholinergic brainstem neurons. In mammals, medial olivocochlear neurons release acetylcholine (ACh) to inhibit outer hair cells to reduce cochlear sensitivity and tuning through an unusual mechanism of nicotinic inhibition, employing unique α9α10-containing AChRs (nAChRs). This synaptic mechanism and orthologous nAChRs, are conserved among vertebrate hair cells. Genetic modification of α9α10-containing nAChRs has cemented the role of efferent feedback in protection against noise-induced hearing loss in mice. Virally-mediated introduction of gain-of-function nAChRs reduces the impact of acoustic trauma in wildtype mice, encouraging development of cholinergic gene therapy for clinical application.

Indexed as

Hair Cells, AuditoryAcetylcholineAnimalsHumansMiceReceptors, NicotinicAcetylcholineReceptors, NicotinicCholinergic gene therapyCochlear hair cellEfferent inhibition

Identifiers

PMID41942802
PMCPMC13237425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.