ArticleJournal of neuro-oncology2026
Multiple presentations: a single pathology, primary central nervous system lymphoma (PCNSL). A multicenter study.
Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary central nervous system lymphoma (PCNSL) is an uncommon extranodal non-Hodgkin lymphoma confined to the brain, spinal cord, leptomeninges, and eyes. Despite its characteristic histology, its neuroimaging appearance is remarkably heterogeneous and often mimics other brain tumors or inflammatory diseases.
methodsWe performed a retrospective analysis of patients diagnosed with PCNSL by members of the Mexican Neuro-Oncology Group. Only cases with histopathological confirmation and pre-treatment contrast-enhanced MRI were included. Lesions were classified according to radiological pattern, number, enhancement characteristics, and anatomical location.
resultsA total of 133 patients met the inclusion criteria. The mean age was 51 years, and 54.2% were men. Seventeen distinct radiological presentation patterns were identified: snowball (58.2%), lymphomatosis cerebri (2.3%), ghost tumor (3.0%), subdural hematoma–like (0.8%), pachymeningeal (2.3%), Ring lesion (5.3%), intraventricular (1.7%), uveal–meningeal (5.9%), isolated intraocular (3.8%), CLIPPERS-like (1.5%), pseudo–multiple sclerosis (3.8%), pseudometastatic (6.0%), primary meningeal (1.5%), pseudoschwannoma (0.8%), pseudomeningioma (2.3%), pseudoadenoma (0.8%), and spinal cord form (0.8%). Deep or periventricular involvement was observed in more than half of the cases.
conclusionsPCNSL exhibits a broad spectrum of neuroradiological patterns that may complicate its recognition. Identifying these atypical presentations is essential to avoid diagnostic delays. Imaging alone is insufficient to establish the diagnosis, underscoring the need for histopathological confirmation. To our knowledge, this represents the largest Latin American series describing the neuroradiological heterogeneity of PCNSL.
Indexed as
Identifiers
41942762What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.