ArticleInternational journal of obesity (2005)2026
Cold-induced metabolic flexibility explains ethnic disparities among individuals with obesity and insulin resistance.
Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCold-induced thermogenesis (CIT) mediated by brown adipose tissue (BAT) and skeletal muscle holds therapeutic utility for obesity, but relative tissue contribution to CIT-driven metabolic flexibility (MetF) and its correlation to insulin resistance remain undefined across diverse ethnicities.
objectiveThis study aimed to investigate ethnic differences in cold-induced MetF and its link to insulin sensitivity in Chinese and Asian Indian individuals with overweight.
designForty-one participants with pre-metabolic or metabolic syndrome of two ethnic groups (31 Chinese, 10 Indian), with an average body mass index (BMI) of 27.5 kg/m
resultsAsian Indians had significantly higher fasting insulin levels and lower insulin sensitivity than Chinese participants. Chinese participants had greater increase in energy expenditure and a more pronounced fuel switch (RER, COX and FOX) with cold. For Chinese individuals, better cold-induced MetF was independently associated with lower fasting insulin and insulin resistance, even after adjusting for age, sex, and body fat. This association was not observed in Asian Indians.
conclusionSignificant ethnic differences exist in the association of CIT-driven MetF to insulin resistance. Chinese individuals exhibited robust MetF-insulin sensitivity correlation, whereas Asian Indians showed a blunted response without such independent association. This suggests that ethnicity-specific strategies targeting MetF are crucial for addressing metabolic health disparities.
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