Evidence map›Paper›PMID 41942740›Full record

ArticleInternational journal of obesity (2005)2026

Genetic risk, antiseizure medications, and lifestyle factors in epilepsy-associated obesity and overweight.

Jiaqi Wang, Zihua He, Sisi Shen, Tong Yi, Shengyi Liu, Quan Yang, Josemir W Sander, Dong Zhou, Xiutian Sima, Jinmei Li

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Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jiaqi Wang *Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Zihua He *Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Sisi ShenDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Tong YiDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Shengyi LiuDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Quan YangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Josemir W SanderDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Dong ZhouDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Xiutian SimaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China. simaxiutian@scu.edu.cn.
Jinmei LiDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China. lijinmei@wchscu.cn.ORCID 0000-0002-7411-8269

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is common among people with epilepsy and is influenced by genetic susceptibility, lifestyle behaviours, and antiseizure medications (ASMs). How ASMs and lifestyle factors interact with genetic risk for obesity in epilepsy remains unclear.

methodsThis population-based cohort study analysed UK Biobank participants with epilepsy recruited between 2006 and 2010. Polygenic risk scores for body mass index (PRS

resultsA total of 8451 individuals were included. In multivariable logistic regression analyses, LTG use was associated with lower odds of obesity (OR = 0.63, 95% CI: 0.47-0.85, P = 0.002) and overweight (OR = 0.72, 95% CI: 0.56-0.92, P = 0.014). VPA was associated with an increased obesity risk (OR = 1.31, 95% CI: 1.07-1.60, P = 0.010). Subgroup analysis suggested that LTG use was associated with a lower risk of obesity, particularly among individuals with low to moderate PRS

conclusionsGenetic predisposition, ASMs, and lifestyle behaviours were collectively associated with the risk of overweight and obesity in epilepsy. LTG use was associated with a lower risk of weight gain, particularly among individuals with lower genetic susceptibility, with this association attenuating as genetic risk for obesity increased. VPA was associated with an increased risk of obesity, especially in females. These findings support personalised metabolic risk management in epilepsy care.

Indexed as

AnticonvulsantsEpilepsyGenetic Predisposition to DiseaseLife StyleObesityOverweightAdultBody Mass IndexCohort StudiesFemaleGenetic Risk ScoreHumansMaleMiddle AgedRisk FactorsUnited KingdomAnticonvulsants

Identifiers

PMID41942740

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