Evidence map›Paper›PMID 41942738›Full record

ReviewHypertension research : official journal of the Japanese Society of Hypertension2026

Epidemiological and clinical evidence on blood pressure management for the prevention of dementia: striving for a healthy 100-year life.

Shintaro Ishida, Miki Kawazoe, Takako Fujii, Yori Inoue, Koichi Yamamoto, Atsushi Sakima, Taku Inoue, Takahiro Komori, Toshiharu Ninomiya, Yoichi Nozato and 15 more

Abstract readReviewEditorial
PubMed Publisher
In one paragraph

Review in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. What is "Implementation Hypertension"? Uniting individuals, healthcare, and society around blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  2. From blood pressure categories to hemodynamic phenotyping in dementia.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  3. Up-to-date hypertension management in the post-guideline era: ending "implementation hypertension".Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Shintaro Ishida *Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Miki Kawazoe *Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Takako FujiiDepartment of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Yori InoueDepartment of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Koichi YamamotoDepartment of Geriatric and General Medicine, The University of Osaka Graduate School of Medicine, Osaka, Japan.
Atsushi SakimaHealth Administration Center, University of the Ryukyus, Okinawa, Japan.
Taku InoueCardiovascular Medicine, Omoromachi Medical Center, Okinawa, Japan.
Takahiro KomoriDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
Toshiharu NinomiyaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yoichi NozatoDepartment of Geriatric and General Medicine, The University of Osaka Graduate School of Medicine, Osaka, Japan.
Takuro KubozonoDepartment of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Hiroshi AkasakaDepartment of Hygiene and Preventive Medicine, Iwate Medical University School of Medicine, Iwate, Japan.
Yume NoharaDivision of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.
Eiichiro YamamotoDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Michiaki NagaiDepartment of Internal Medicine, Hiroshima Asa Medical Association Hospital, Hiroshima, Japan.
Masafumi IharaDepartment of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Yoichi TakamiDepartment of Geriatric and General Medicine, The University of Osaka Graduate School of Medicine, Osaka, Japan.
Shuko TakedaDepartment of Clinical Gene Therapy, The University of Osaka Graduate School of Medicine, Osaka, Japan.
Toru YamashitaDepartment of Neurology, University of Toyama, Toyama, Japan.
Shigeru ShibataDivision of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Koichi NodeDepartment of Cardiovascular Medicine, Saga University, Saga, Japan.
Kazuomi KarioDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
Masaki MogiDepartment of Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan.
Hisatomi ArimaDepartment of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. harima@fukuoka-u.ac.jp.
Working Group for the Prevention of Cognitive Impairment by Hypertension Management (PCIHM) of the Japanese Society of Hypertension

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As Japan faces rapid population aging, understanding modifiable risk factors for dementia is critical. This review explores the impact of hypertension and blood pressure (BP) management on dementia onset. Midlife hypertension emerges as a key risk factor, especially for vascular dementia, while late-life BP effects are variable. Observational studies suggest a critical window for intervention between ages 55-74. Moreover, BP variability independently predicts cognitive decline. Though randomized controlled trials show mixed outcomes, meta-analyses suggest that intensive BP lowering may reduce dementia risk, particularly in settings where BP reductions are substantial. These results suggest that systolic BP of <130 mmHg is desirable and support lower and stable BP control from early age as a public health strategy to delay the onset of dementia. The Japanese Society of Hypertension emphasizes three fundamental principles of BP management-early initiation, lower BP in midlife, and stable control-for preventing dementia/cognitive impairment.

Indexed as

Antihypertensive AgentsBlood PressureDementiaHypertensionAgedAged, 80 and overHumansRisk FactorsAntihypertensive AgentsBlood pressureDementiaImplemental hypertensionObservational studyRandomized controlled trial

Identifiers

PMID41942738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.