Evidence map›Paper›PMID 41942684›Full record

ArticleNeuroscience bulletin2026

Circuit Mechanisms Underlying the Contribution of Leptin Receptor-Expressing Neurons in the Nucleus Tractus Solitarius to Ventilatory Homeostasis.

Yinchao Hao, Mengchu Zhu, Hongxiao Yu, Xiang Zhang, Yishuo Shi, Lu Sun, Yaxin Hao, Yifei Huang, Lingxiao Yu, Sheng Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yinchao Hao *Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Mengchu Zhu *Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Hongxiao YuDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Xiang ZhangDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Yishuo ShiDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Lu SunDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Yaxin HaoDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Yifei HuangDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Lingxiao YuDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Sheng WangDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Dongxing ZhaoState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510162, China. rieast@163.com.
Fang YuanDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China. yuanfang@hebmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep apnea syndrome (SAS) is a prevalent disorder characterized by recurrent respiratory pauses during sleep; however, the neural mechanisms governing respiratory stability remain poorly understood. In this study, we identify the ratio of sigh expiratory volume to eupneic expiratory volume as a potential predictor of post-sigh apnea in susceptible C57BL/6J mice. We demonstrate that leptin signaling within the nucleus tractus solitarius (NTS) is critical for maintaining respiratory drive and suppressing apnea. Chemogenetic activation of Leptin receptor b-expressing NTS (NTS

Indexed as

HomeostasisNeuronsReceptors, LeptinRespirationSleep Apnea SyndromesSolitary NucleusAnimalsLeptinMaleMiceMice, Inbred C57BLNeural PathwaysLeptinReceptors, LeptinLeptinNeural circuitNucleus tractus solitariusSleep apnea

Identifiers

PMID41942684
PMCPMC13642890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.