SynthesisScientific reports2026
Gait asymmetry in Parkinson's disease - a systematic review and meta-analysis (AsymmGait-Parkinson study).
Synthesis in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Sex- and Laterality-Specific Associations Between Serum Uric Acid-to-Creatinine Ratio and Gait Parameters in Parkinson's Disease.Brain and behavior · 2026Article
- Whole body analysis of functional communities and topological features of gait with different speeds in Parkinson's disease.Journal of neurology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Gait asymmetry (GA) in people with Parkinson’s disease (pwPD) has been inconsistently reported, leading to uncertainty about its prevalence and clinical significance. GA may relate to motor symptoms’ lateralization and the effects of dopaminergic medication. The aim of this study was to systematically summarize the current literature and perform a meta-analysis to investigate the differences between GA in pwPD compared to healthy individuals and to evaluate the effect of dopaminergic medication on GA. The review was registered in PROSPERO database (ID: CRD42021285067). The searching was conducted in the PubMed, Cochrane Library, Lilacs, PEDro and Scopus databases. The primary search resulted in 551 studies. After removing the duplicates, 451 studies remained for the analysis. After checking the full text, 42 studies with 2111 pwPD were included in this review. The meta-analysis showed that pwPD exhibited greater asymmetry in step length, step time, and swing time, particularly in the OFF state, with moderate effect sizes. Dopaminergic medication was associated with reduced swing time asymmetry. Temporal aspects of GA, particularly swing time asymmetry, was most sensitive to detect differences in GA between pwPD and healthy controls and to indicate an effect of dopaminergic medication. The inconsistent findings across studies highlight the need for standardization in GA measurement. Understanding the neural mechanisms underlying GA may improve targeted therapies. Further research should explore GA in more challenging walking conditions and in free-living environments to enhance the clinical understanding of gait disturbances in PD.
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Registered trials
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