Evidence map›Paper›PMID 41942666›Full record

ArticleBulletin of experimental biology and medicine2026

Analysis of the Ciliotoxic Effects of an Intranasal In Situ Ribavirin Delivery System: In Vitro and In Vivo Evaluation.

I B Mikhel, E O Bakhrushina, D N Tikhonov, V I Shchekin, A A Nedorubov, O I Stepanova, I I Krasnyuk

Abstract read
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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

I B MikhelI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. mikheliosif@gmail.com.
E O BakhrushinaI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
D N TikhonovI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
V I ShchekinNational Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Moscow, Russia.
A A NedorubovI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
O I StepanovaI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
I I KrasnyukI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intranasal route of drug administration offers a number of advantages, including the possibility of direct brain targeting while bypassing the blood-brain barrier. The local effect of an innovative ribavirin in situ gel on the nasal mucosa of outbred rats was investigated. Twelve formulations containing ion-sensitive polymers were evaluated in vitro and their physicochemical properties were assessed. The formulation containing 0.5% gellan gum and 2% Poloxamer-124 was recognized as optimal, exhibiting the most suitable technological characteristics. In vivo experiments confirmed the absence of irritating effect on the surface of the nasal mucosa in experimental animals. These findings highlight the potential of this dosage form for the treatment of brain tumors.

Indexed as

Antiviral AgentsCiliaDrug Delivery SystemsNasal MucosaRibavirinAdministration, IntranasalAnimalsMalePoloxamerPolysaccharides, BacterialRatsAntiviral Agentsgellan gumPoloxamerPolysaccharides, BacterialRibavirinciliotoxic effecthistological studyintranasal in situ delivery systemsin vivo studiesribavirin

Identifiers

PMID41942666

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.