ArticleScientific reports2026
Pioneering ultrastructural texture analysis of dendrites in the cerebellar dentate nucleus: an experimental rat model of hyperthermia-induced seizures.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The study objective was descriptive, qualitative and quantitative texture analysis of ultrastructural research of the dendritic domain, especially dendrites, within the cerebellar dentate nucleus (DN) in an experimental model of hyperthermia-induced seizures (HS) developed at our Center, conducted on young Wistar rats. Specimens (1 mm³) collected from the DN in both experimental and control groups, and fixed via transcardial perfusion with paraformaldehyde and glutaraldehyde solutions, were routinely processed for transmission electron microscopy. Ultrastructural studies, including morphometric assessment of dendrites across the DN in the experimental model of hyperthermia-induced seizures (HS), revealed distinctive and easily recognizable morphological signs of aponecrosis, manifested as "dark" dendroplasm degeneration ("dark dendrites"), resulting in significant disturbances in the cerebro-cerebellar function in animals subjected to hyperthermic stress. The aponecrotic lesions affecting the dendritic tree were characterized by shrunken, dark, nearly black, homogeneous dendroplasm exhibiting intense degenerative changes up to and including necrosis, which fully correlated with the quantitative analysis. Lethally damaged large dendrites displayed clear signs of cytoskeletal disintegration within the dendrites, particularly affecting microtubules, which are critical structures involved in numerous cellular processes, as well as cytoplasmic organelles. Our current and previous pioneering qualitative and quantitative ultrastructural investigations into the cellular mechanisms underlying the experimental model of HS indicate that damage to the somatodendritic domain of DN, including dendritic arborization and neuronal somata, characterized by aponecrosis, may play a major role in the morphogenesis of heat stress-induced convulsions.
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