Evidence map›Paper›PMID 41942471›Full record

ArticleNature communications2026

Dissecting PGE

Zhongli Xu, Shiyue Tao, Site Feng, Xiangyu Ye, Ting Wang, Haoran Hu, Elisa Heidrich-O'Hare, Wei Chen, Richard H Duerr

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Dissecting PGENature communications · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhongli Xu *Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-6843-6212
Shiyue Tao *Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Site FengSchool of Medicine, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0002-3946-4043
Xiangyu YeDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Ting WangDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Haoran HuDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-3619-2852
Elisa Heidrich-O'HareDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Wei ChenDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. wei.chen@pitt.edu.ORCID http://orcid.org/0000-0001-7196-8703
Richard H DuerrDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. duerr@pitt.edu.ORCID http://orcid.org/0000-0001-6586-3905

Funding

NIDDK IBD Genetics Consortium Genetic Research CenterU01DK062420 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUERR, RICHARD H · 2002 to 2021
$7.8M
Trans-ancestry, single-cell multiomics dissection of IBD-associated loci in CD4 memory T cellsR01DK138458 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Wei Chen, Richard H Duerr · 2024 to 2026
$1.4M
NIDDK NIH HHS R01 DK138458NIDDK NIH HHS U01 DK062420U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK138458U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) U01DK062420
6 · The paper itself

Abstract

Genetic and immunologic studies implicate the interleukin (IL)-23/T helper (Th)17 pathway in inflammatory bowel disease (IBD). IL-23 and IL-1β drive human Th17 differentiation, while prostaglandin E2 (PGE

Indexed as

DinoprostoneInflammatory Bowel DiseasesLymphocyte ActivationT-LymphocytesCell DifferentiationChromatinGenetic Association StudiesHumansInterleukin-1betaInterleukin-23MultiomicsPolymorphism, Single NucleotideSingle-Cell AnalysisTh17 CellsT-Lymphocytes, RegulatoryTransforming Growth Factor betaChromatinDinoprostoneInterleukin-1betaInterleukin-23Transforming Growth Factor beta

Identifiers

PMID41942471
PMCPMC13269560

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.