Evidence map›Paper›PMID 41942466›Full record

Articlenpj aging2026

Biomarkers of oxidative damage as a tool to investigate frailty syndrome in older women.

Magdalena Sepúlveda, Iván Palomo, Felipe Lagos, Ximena Pardo, Camilo López-Alarcón, Felipe Ávila, Eduardo Fuentes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Magdalena SepúlvedaThrombosis Research and Healthy Aging Center, Medical Technology School, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca; Interuniversity Center for Healthy Aging (CIES); Interuniversity Network of Healthy Aging in Latin America and Caribbean (RIES-LAC); Vitalis-Longevity Center, Faculty of Health Sciences, Universidad de Talca, Talca, Chile.
Iván PalomoThrombosis Research and Healthy Aging Center, Medical Technology School, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca; Interuniversity Center for Healthy Aging (CIES); Interuniversity Network of Healthy Aging in Latin America and Caribbean (RIES-LAC); Vitalis-Longevity Center, Faculty of Health Sciences, Universidad de Talca, Talca, Chile.
Felipe LagosThrombosis Research and Healthy Aging Center, Medical Technology School, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca; Interuniversity Center for Healthy Aging (CIES); Interuniversity Network of Healthy Aging in Latin America and Caribbean (RIES-LAC); Vitalis-Longevity Center, Faculty of Health Sciences, Universidad de Talca, Talca, Chile.
Ximena PardoDepartamento de Ciencias de la Nutrición y los Alimentos, Escuela de Nutrición y Dietética, Facultad de Ciencias de la Salud, Universidad de Talca, Talca, Chile.
Camilo López-AlarcónDepartamento de Química Física, Escuela de Química, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile.
Felipe ÁvilaDepartamento de Ciencias de la Nutrición y los Alimentos, Escuela de Nutrición y Dietética, Facultad de Ciencias de la Salud, Universidad de Talca, Talca, Chile. favilac@utalca.cl.
Eduardo FuentesThrombosis Research and Healthy Aging Center, Medical Technology School, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca; Interuniversity Center for Healthy Aging (CIES); Interuniversity Network of Healthy Aging in Latin America and Caribbean (RIES-LAC); Vitalis-Longevity Center, Faculty of Health Sciences, Universidad de Talca, Talca, Chile. edfuentes@utalca.cl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frailty syndrome (FS) is a critical factor associated with several oxidative stress and age-related diseases. In this work, we investigated the connection between frailty, defined at early stages using a new cut-off value of the Frailty Trait Scale (FTS-5), and plasma biomarkers of oxidative stress. Plasma samples of 76 older women were analyzed to determine free and protein-bounded tryptophan (Trp), kynurenine (Kyn), N-formylKynurenine (N-Kyn), advanced glycation end products, and protein carbonylation. A subgroup of 30 subjects was selected from the entire group to determine malondialdehyde (MDA), free methionine (Met), phenylalanine (Phe), Trp, and Kyn. In the whole group (N = 76), Kyn and the Kyn/Trp ratio were higher in women with a Romberg test altered (p-values = 0.0439, and 0.0472, respectively) and BMI < 25.3 kg/m

Identifiers

PMID41942466
PMCPMC13230943

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.