Evidence map›Paper›PMID 41942426›Full record

ArticleNature communications2026

Nickel-catalyzed ring-opening difunctionalization of methylenecyclobutanes via strain-release-enabled C-C activation.

Tingting Wang, Haina Liu, Meihong Luo, Wen-Wen Zhao, Chao Ma, Mingshuai Zhang, Jian-Biao Liu, Hongyu Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tingting Wang *Key Laboratory of Marine Drugs, Ministry of Education; Molecular Synthesis Center, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China.
Haina Liu *Key Laboratory of Marine Drugs, Ministry of Education; Molecular Synthesis Center, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China.
Meihong Luo *Key Laboratory of Marine Drugs, Ministry of Education; Molecular Synthesis Center, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China.
Wen-Wen Zhao *College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, PR China.
Chao MaKey Laboratory of Marine Drugs, Ministry of Education; Molecular Synthesis Center, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China.
Mingshuai ZhangKey Laboratory of Marine Drugs, Ministry of Education; Molecular Synthesis Center, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China.
Jian-Biao LiuCollege of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, PR China. jianbiaoliu.thu@sdnu.edu.cn.ORCID http://orcid.org/0000-0002-2550-3355
Hongyu WangKey Laboratory of Marine Drugs, Ministry of Education; Molecular Synthesis Center, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China. why@ouc.edu.cn.ORCID http://orcid.org/0000-0001-5720-6542

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22377113Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2024MB140Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2025QB23Taishan Scholar Foundation of Shandong Province tsqn202306103
6 · The paper itself

Abstract

The efficient construction of molecular complexity from simple building blocks is a significant goal in catalysis, and the controlled ring-opening functionalization of strained carbocycles provides a powerful strategy to achieve it. However, selective catalytic strategies for ring-opening difunctionalization of methylenecyclobutanes (MCBs) remain elusive. Here, we report a nickel-catalyzed method that enables the 1,4-dicarbofunctionalization and 1,4-hydrocarbofunctionalization of MCBs via selective C-C bond cleavage. This protocol exploits the strain energy and dual reactivity of MCBs to deliver nonadjacent C(sp

Identifiers

PMID41942426
PMCPMC13230889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.