ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2026
Association of Systemic Inflammatory Indices with Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis.
Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimsThe newly proposed metabolic dysfunction-associated steatotic liver disease (MASLD) framework reflects the evolving understanding of fatty liver disease, highlighting the importance of exploring novel risk factors beyond traditional metabolic indicators. This study aimed to examine the associations between systemic inflammatory indices and the prevalence of MASLD and liver fibrosis. MATERIALS AND
methodsData from the 2017 MASLD framework reflecting the evolving regression was used to assess associations of systemic inflammatory indices-systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), platelet- to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index (PNI), aggregate index of systemic inflammation (AISI), inflammation burden index (IBI), neutrophil-to-lymphocyte ratio, neutrophil-to-albumin ratio, and pan-immuneinflammation value (PIV)-with MASLD assessed by controlled attenuation parameter (CAP) and liver fibrosis assessed by liver stiffness measurement (LSM), adjusting for confounders.
resultsAnalysis of CAP and MASLD revealed that elevated SII, SIRI, LMR, IBI, and PNI were significantly associated with higher CAP values, reflecting increased hepatic steatosis, while PLR showed a negative association. Regarding LSM and liver fibrosis, higher SIRI, PNI, IBI, and AISI were significantly associated with increased liver stiffness, whereas PLR remained inversely correlated.
conclusionThis nationally representative study demonstrates that systemic inflammatory dysregulation is linked to both MASLD and liver fibrosis, with distinct biomarker patterns for steatosis and fibrosis.
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