ArticleProceedings of the National Academy of Sciences of the United States of America2026
Mycoviruses confer hypovirulence but enhance antifungal volatile organic compound production in a phytopathogenic fungus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Advances in the Control of Plant Fungal Pathogens.Journal of fungi (Basel, Switzerland) · 2026Review
- Mycoviruses confer hypovirulence but enhance antifungal volatile organic compound production in a phytopathogenic fungus.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mycoviruses as Biocontrol Agents: Potential Applications for Managing Pests and Diseases of Oilseed Rape (Brassica napus).Physiologia plantarumReview
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Authors and funding
18 authors.
Funding
Abstract
Hypovirulence-associated mycoviruses can be frequently isolated in nature despite their likely compromised ecological fitness, but how their fungal hosts survive in natural environments remains largely unresolved. The discovery of more mycoviruses provides opportunities to understand these mycovirus-host relationships. Here, we characterize a capsidless RNA virus, Sclerotinia sclerotiorum ascoshuvirus 1 (SsAShV1), with a 10.7-kb ssRNA genome encoding a polyprotein containing conserved protease domain and RNA-dependent RNA polymerase (RdRP) domain. SsAShV1 shares structural similarities with animal-infecting viruses. SsAShV1 and its phylogenetically related shuviruses form a distinct evolutionary lineage, prompting the proposal to establish the family Shuviridae. SsAShV1 transfection alone induces hypovirulence in two Sclerotiniaceae fungal pathogens, with its 3'-UTR repeat-containing structural region (RCSR) enhancing replication efficiency. In the hypovirulent strain SCH767, which harbors SsAShV1 and five other mycoviruses, we observed a synergistic enhancement of antifungal volatile organic compound (VOC) production that was dependent on the host genetic background. A VOC, 2-ethyl-1-hexanol, exhibited broad-spectrum antimicrobial activity. Our findings reveal an evolutionary trade-off where viral infection shifts the fungal survival strategy from high virulence to enhanced chemical competition, ensuring the persistence of the hypovirulent partnership, and offering valuable insights into the development of a combination of mycovirus-based and VOC-mediated biocontrol strategies.
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