Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Lucien P Garo *Pulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02119.ORCID 0000-0001-5369-1958
Kevin Brueck *Pulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02119.
Sarah WalachowskiPulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02119.ORCID 0000-0001-5702-3404
Archana JayaramanPulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02119.ORCID 0000-0003-0871-6305
Marcel StrueveCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz 55131, Germany.ORCID 0000-0002-0296-4343
Shuang XuPulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02119.ORCID 0009-0004-7731-5585
Hulbert YangPulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02119.ORCID 0009-0007-4371-4790
Matthew HelmkampPulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02119.ORCID 0009-0005-7657-3301
Seung Hoan ChoiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02119.
Christoph ReinhardtCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz 55131, Germany.ORCID 0000-0002-0696-2636
Markus BosmannPulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02119.ORCID 0000-0003-2773-1033
Funding
BIOLOGY OF THE LUNG--MULTIDISCIPLINARY PROGRAMT32HL007035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, JOSEPH P MIZGERD · 1985 to 2026
$24.3M
Interleukin-27 in host response to Legionella infectionR01HL166588 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Markus Bosmann · 2023 to 2026
$2.8M
Role reversal of MAVS in bacterial sepsisR01HL141513 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOSMANN, MARKUS · 2018 to 2022
$2.4M
New genetic models for C5a receptorsR01HL139641 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOSMANN, MARKUS · 2018 to 2022
$2.1M
Full Spectrum Cell Sorter with Imaging Enhancement for Boston University Flow Cytometry Core FacilityS10OD038346 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BELKINA, ANNA · 2025 to 2025
$656k
The Role of Proton-Activated Chloride Channel 1 (PACC1) in Bacterial Pneumonia and SepsisF31HL176388 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Lucien Peter Garo · 2024 to 2026
Bacterial sepsis remains a devastating clinical problem. Here, we describe a protective role for the recently discovered acid-sensitive, proton-activated chloride channel, PACC1 (PAC/ASOR/TMEM206), during sepsis. Initially, we found PACC1 was enriched in healthy human and mouse mononuclear phagocytes, particularly macrophages, and differentially regulated by inflammatory stimuli, suggesting PACC1 involvement in innate immunity. To further investigate, we generated
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis. · full record | OpenQuestion