Evidence map›Paper›PMID 41941620›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Extracellular matrix chemistry tunes bacterial biofilm metabolism and optimizes fitness.

Jinyang Li, Georgia R Squyres, Kathy Duong, Courtney Reichhardt, Matthew R Parsek, Dianne K Newman

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jinyang LiDivision of Biology and Biological Engineering, Caltech, Pasadena, CA 91125.ORCID 0000-0003-3190-4021
Georgia R SquyresDivision of Biology and Biological Engineering, Caltech, Pasadena, CA 91125.ORCID 0000-0002-8717-2897
Kathy DuongDepartment of Chemistry, Washington University, St. Louis, MO 63130.
Courtney ReichhardtDepartment of Chemistry, Washington University, St. Louis, MO 63130.ORCID 0000-0002-1022-5110
Matthew R ParsekDepartment of Microbiology, University of Washington, Seattle, WA 98195.ORCID 0000-0003-2932-7966
Dianne K NewmanDivision of Biology and Biological Engineering, Caltech, Pasadena, CA 91125.ORCID 0000-0003-1647-1918

Funding

The pel exopolysaccharide gene cluster of Pseudomonas aeruginosaR01AI077628 · NIAID · UNIVERSITY OF WASHINGTON · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2009 to 2026
$7.1M
Biological mechanisms and consequences of efficient extracellular electron transfer in Pseudomonas aeruginosaR01AI127850 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Dianne K Newman · 2017 to 2026
$5.6M
Damon Runyon Cancer Research Foundation (DRCRF) DRG 2439-21HHS | National Institutes of Health (NIH) 2R01AI127850-06A1NIAID NIH HHS R01 AI077628NIAID NIH HHS R01 AI127850
6 · The paper itself

Abstract

Chemically complex extracellular matrices define cellular microenvironments and shape cell behavior across all domains of life. But how has evolution optimized these materials to ensure the success of multicellular communities? Inspired by the well-established composition-properties-function relationships in engineered materials, we hypothesized that analogous relationships exist in extracellular matrices, where the composition and interactions among various matrix components govern material properties and cellular physiology. Here, we examine

Indexed as

BiofilmsExtracellular MatrixPseudomonas aeruginosaElectron TransportOxygenPyocyanineOxygenPyocyaninebiofilmsextracellular electron transferextracellular matrixliving materialsphenazines

Identifiers

PMID41941620
PMCPMC13055754

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.