ArticleJournal of visualized experiments : JoVE2026
A Hypoxia-reoxygenation Injury Model in Self-assembling Human Cardioids.
Article in Journal of visualized experiments : JoVE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Automated processing pipeline for functional imaging of human cardiac organoids using optical coherence tomography.Biomedical optics express · 2026Article
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Authors and funding
15 authors.
Funding
Abstract
Without rapid revascularization, ischemic heart disease leads to irreversible loss of cardiomyocytes, scar formation, and decreased cardiac function. The ability to model hypoxia-reoxygenation injuries and evaluate potential therapeutic interventions in human tissues is an unmet need. Human cardiac organoids (hCOs) are an emerging model system, but beginning work with hCOs can be challenging due to their small size, requirements for suspension culture, and variability in differentiation efficiency. This protocol offers a user-friendly guide for generating and maintaining human iPSC-derived self-assembling hCOs; methods to process and histologically analyze hCOs; and an approach to injure hCOs with hypoxia-reoxygenation that mimics the fibrosis and apoptosis seen with human ischemia/reperfusion. This protocol provides guidance for using hCOs as a complement to animal models of ischemia-reperfusion injury and could be used to identify and test factors that may boost human myocardial recovery.
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Registered trials
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