ArticlePloS one2026
Platelet-rich plasma for immature post-traumatic scars and early keloids: A scoping review.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Intervention With Autologous Platelet-Containing Plasma for Immature Atrophic Facial Scars: A Quantitative Case Study.Clinical case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-traumatic cutaneous scars enter an immature phase after re-epithelialization, characterized by ongoing inflammation and active remodeling. This phase, typically within six months of injury, may allow preventive interventions before pathological scarring develops. Platelet-rich plasma (PRP) has been suggested as a modulator of scar remodeling due to its growth factor content, but its role in immature scars has not been systematically reviewed.
objectiveTo map and summarize the clinical evidence on autologous platelet-containing plasma (ACP), including platelet-rich plasma (PRP), for immature post-traumatic scars and early keloids, and to identify gaps for future research.
methodsA scoping review was performed following established frameworks and reporting guidelines. Databases including PubMed/MEDLINE, DOAJ, SciELO, LILACS, and Google Scholar were searched. Studies evaluating ACP or PRP applied to post-traumatic scars within six months post-epithelialization were included.
resultsFive studies involving 65 patients met inclusion criteria, including randomized trials, observational studies, and case reports. PRP was mainly delivered via intralesional injection. Evidence suggests PRP may improve clinical scar scores and patient-reported outcomes, with no serious adverse events reported. However, studies were heterogeneous in PRP preparation, dosing, timing, and outcome measures. No study was designed to assess PRP as a preventive monotherapy.
conclusionsEvidence for PRP in immature post-traumatic scars and early keloids is extremely limited and heterogeneous. While preliminary findings indicate potential benefit and safety, current data are insufficient to support routine preventive use. High-quality, prospective studies are needed to determine whether PRP can influence scar remodeling or prevent pathological scarring.
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