Evidence map›Paper›PMID 41941379›Full record

ArticleJournal of medicinal chemistry2026

Discovery of Novel 2-Morpholine Tetrahydroisoquinoline CXCR4 Antagonists with Unique Properties.

Yesim Altas Tahirovic, Zafer Sahin, Edgars Jecs, Eric J Miller, Huy H Nguyen, Robert J Wilson, Michelle Kim, Marshall Fritz, Yusr Zaghlula, Savita K Sharma and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yesim Altas TahirovicDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Zafer SahinDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Edgars JecsDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.ORCID 0000-0002-2428-3899
Eric J MillerDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.ORCID 0000-0003-3659-0105
Huy H NguyenDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Robert J WilsonDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.ORCID 0000-0002-8344-5325
Michelle KimDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Marshall FritzDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Yusr ZaghlulaDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Savita K SharmaDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Perry BartschDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Tao WangBristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.
Chi S SumBristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.
Mary E CvijicBristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.
Anthony A PaivaBristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.
Gretchen M SchroederBristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.
Lawrence J WilsonDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.ORCID 0000-0002-6895-1051
Dennis C LiottaDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.ORCID 0000-0002-7736-7113

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The exploration of tetrahydroisoquinoline-based CXCR4 antagonists as therapeutics is described. Starting from TIQ-15, halogen and heterocycle derivatives led to the identification of the 2-position N-morpholine. The initial compounds,

Indexed as

MorpholinesReceptors, CXCR4TetrahydroisoquinolinesAdministration, OralAnimalsBiological AvailabilityCytochrome P-450 CYP2D6Cytochrome P-450 CYP2D6 InhibitorsDrug DiscoveryHumansMiceStructure-Activity RelationshipCXCR4 protein, humanCytochrome P-450 CYP2D6Cytochrome P-450 CYP2D6 InhibitorsMorpholinesReceptors, CXCR4Tetrahydroisoquinolines

Identifiers

PMID41941379
PMCPMC13126686

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.