Evidence map›Paper›PMID 41941253›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2026

Long-term function and oncologic outcomes following nerve spare or wide resection during radical prostatectomy.

Ameeta L Nayak, Simon Pupulin, Ahsas Nagee, Luke T Lavallée, Ranjeeta Mallick, Anathea S Flaman, Chris Morash, Ilias Cagiannos, Rodney H Breau

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Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ameeta L NayakDivision of Urology, Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Simon PupulinDepartment of Medicine, University of Ottawa, Ottawa, ON, Canada.
Ahsas NageeDepartment of Medicine, University of Ottawa, Ottawa, ON, Canada.
Luke T LavalléeDivision of Urology, Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Ranjeeta MallickOttawa Hospital Research Institute, Ottawa, ON, Canada.
Anathea S FlamanOttawa Hospital Research Institute, Ottawa, ON, Canada.
Chris MorashDivision of Urology, Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Ilias CagiannosDivision of Urology, Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Rodney H BreauDivision of Urology, Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNerve sparing during radical prostatectomy (RP) is associated with improved postoperative erectile function and urinary continence but may increase the risk of positive surgical margins. This study sought to compare the long-term outcomes of patients treated with nerve spare (NS) compared to wide resection (WR).

methodsA historical cohort of consecutive patients was reviewed. A standardized surgical approach of lobe-specific NS or WR was performed. The primary outcome was treatment failure, defined as prostate-specific antigen (PSA) recurrence (PSA ≥0.2 ng/mL) or receipt of postoperative radiation. Secondary outcomes included time to metastases, urinary continence, and erectile function.

resultsOf 193 consecutive patients, 123 (63%) received bilateral NS, 36 (19%) received unilateral NS, and 34 (18%) bilateral WR. Patients undergoing any NS had lower preoperative PSA, tumor stage, and grade group compared to WR patients (all p<0.05). Adjusting for these variables, the risk of treatment failure (PSA ≥2 ng/mL or postoperative radiation) was increased in patients who underwent NS compared to WR (hazard ratio [HR] 2.46, 95% confidence interval [CI] 1.25-4.83). Urinary continence recovered more quickly after NS, but by 24 months post-RP, this difference was not statistically significant (bilateral NS: risk ratio [RR] 1.10, 95% CI 0.95-1.30; unilateral NS: RR 1.01, 95% CI 0.82-1.24). Postoperative erectile function was better in patients receiving unilateral or bilateral NS (unilateral: 21%, bilateral: 59%, WR: 0%).

conclusionsNS during RP was associated with higher risk of treatment failure, but better functional outcomes compared to WR. These results indicate that NS presents a tradeoff of outcomes that must be matched to individual patient's values and preferences.

Identifiers

PMID41941253
PMCPMC13423253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.