Evidence map›Paper›PMID 41941000›Full record

ArticleHistochemistry and cell biology2026

Fibre morphology, intramyocellular lipid content and 3D capillary architecture in human postural, respiratory and locomotor muscles in type 2 diabetes mellitus.

Nataša Pollak, Jiří Janáček, František Saudek, Erika Cvetko, Barbora Radochová, Armin Alibegović, Chiedozie Kenneth Ugwoke, Davide Alessandro Basello, Žiga Šink, Luka Pušnik and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Histochemistry and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. April In focus in HCB: skeletal muscle fibers.Histochemistry and cell biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nataša PollakInstitute of Anatomy, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia. natasa.pollak@mf.uni-lj.si.ORCID http://orcid.org/0000-0003-3429-4441
Jiří JanáčekLaboratory of Advanced Microscopy and Data Analyses, Institute of Physiology, The Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0003-0286-4999
František SaudekDiabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-0448-4351
Erika CvetkoInstitute of Anatomy, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0002-4414-5928
Barbora RadochováLaboratory of Advanced Microscopy and Data Analyses, Institute of Physiology, The Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-5869-539X
Armin AlibegovićInstitute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0001-8016-7537
Chiedozie Kenneth UgwokeInstitute of Anatomy, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0003-4143-369X
Davide Alessandro BaselloLaboratory of Advanced Microscopy and Data Analyses, Institute of Physiology, The Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0009-0007-7852-9771
Žiga ŠinkInstitute of Anatomy, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0009-0007-2454-6592
Luka PušnikInstitute of Anatomy, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0003-3418-0348
Rok Tit TomazinInstitute of Anatomy, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0001-6379-9516
Nejc UmekInstitute of Anatomy, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0001-5831-2216

Funding

Grantová Agentura České Republiky 22-02756KMinisterstvo Školství, Mládeže a Tělovýchovy CZ.02.1.01/0.0/0.0/18_046/0016045The Slovenian Research and Innovation Agency P3-0043 and N3-0256
6 · The paper itself

Abstract

In type 2 diabetes mellitus (T2DM), skeletal muscle is a major site of metabolic and microvascular dysfunction, yet most human data derive from large locomotor muscles, whereas postural and respiratory muscles remain less well characterised. We examined whether T2DM alters fibre morphology, intramyocellular lipid (IMCL) content, and three-dimensional (3D) capillary architecture across functionally distinct muscles. Postural (splenius capitis [SC]), respiratory (diaphragm [DIA]; external intercostal [EXT]), and locomotor (vastus lateralis [VL]) muscles from adult male individuals (T2DM versus control, n = 24/group) were sampled < 24 h post-mortem. Analysis included myosin heavy chain fibre typing, Sudan Black B intramyocellular lipid (IMCL) quantification, and 3D capillary morphometry (length, tortuosity, anisotropy, branching density). Groups were age-matched (T2DM 70.8 ± 7.4 versus 69.7 ± 11.8 years; p = 0.684), but body mass index (BMI) was higher in T2DM (31.9 ± 4.7 versus 24.8 ± 2.7 kg m

Indexed as

CapillariesDiabetes Mellitus, Type 2LipidsMuscle Fibers, SkeletalMuscle, SkeletalRespiratory MusclesAgedHumansMaleMiddle AgedLipids3D capillary morphometryIntramyocellular lipidMetabolic myopathyMyosin heavy chain isoformsSkeletal muscleType 2 diabetes mellitus

Identifiers

PMID41941000
PMCPMC13053442

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.