ArticleWorld journal of urology2026
Functional outcome and quality of life (QoL) in patients undergoing radical prostatectomy without prior prostate biopsy.
Article in World journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
purposeTo evaluate the impact of omitting preoperative biopsy on postoperative functional outcomes and health-related quality of life (HRQOL) in patients undergoing radical prostatectomy (RP).
methodsThis retrospective cohort study used data from the prostatectomy database at LMU University Hospital. Patients were divided into a biopsy group (n = 8995) and a non-biopsy group (n = 68). Propensity score matching was performed to control for confounders, resulting in a matched cohort (biopsy group n = 186, non-biopsy group n = 68). Urinary continence (ICIQ-SF, pads/day), sexual function (IIEF-5), and HRQOL (EORTC QLQ-C30) were compared between the two groups at multiple time points (preoperatively and at 3–48 months postoperatively) in matched and unmatched cohorts, and also in pT2 subgroups.
resultsAll patients in the non-biopsy group had highly suspected prostate cancer and were pathologically confirmed to have significant prostate cancer. In the matched cohort, HRQOL was significantly better in the biopsy group at 3 months. In the matched cohort, the non-biopsy group showed no advantage regarding continence and sexual function, but higher symptom burden at several time points. Similar trends were observed in the pT2 subgroups.
conclusionThis study showed no evidence of a clinically relevant difference regarding functional or HRQOL outcome after RP between patients with and without preoperative prostate biopsy.
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