Evidence map›Paper›PMID 41940983›Full record

ReviewSeminars in immunopathology2026

Butyrate remodels the immune-epigenetic-gut-lung axis: Emerging mechanisms and therapeutic perspectives in asthma.

Yuqia Xie, Guochun Huang, Jun Zhao, Zhicheng Yuan, Hangyu Li, Jingyi Deng, Daichi Chen, Wenlu Zhu, Gonghua Huang, Yuanhui Li and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Seminars in immunopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuqia Xie *Shunde Woman and Children's Hospital of Guangdong Medical University, College of Medical Technology, Guangdong Medical University, Dongguan, 523808, China.
Guochun Huang *Shunde Woman and Children's Hospital of Guangdong Medical University, College of Medical Technology, Guangdong Medical University, Dongguan, 523808, China.
Jun Zhao *Dongguan Key Laboratory of Immunoregulation and Prevention of Pulmonary Diseases, Liaobu Hospital of Dongguan City, Dongguan, 523430, China.
Zhicheng YuanShunde Woman and Children's Hospital of Guangdong Medical University, College of Medical Technology, Guangdong Medical University, Dongguan, 523808, China.
Hangyu LiShunde Woman and Children's Hospital of Guangdong Medical University, College of Medical Technology, Guangdong Medical University, Dongguan, 523808, China.
Jingyi DengShunde Woman and Children's Hospital of Guangdong Medical University, College of Medical Technology, Guangdong Medical University, Dongguan, 523808, China.
Daichi ChenShunde Woman and Children's Hospital of Guangdong Medical University, College of Medical Technology, Guangdong Medical University, Dongguan, 523808, China.
Wenlu ZhuShunde Woman and Children's Hospital of Guangdong Medical University, College of Medical Technology, Guangdong Medical University, Dongguan, 523808, China.
Gonghua HuangGuangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, Guangdong Medical University, Dongguan, 523808, China.
Yuanhui LiDongguan Key Laboratory of Immunoregulation and Prevention of Pulmonary Diseases, Liaobu Hospital of Dongguan City, Dongguan, 523430, China. 343430543@qq.com.
Suidong OuyangShunde Woman and Children's Hospital of Guangdong Medical University, College of Medical Technology, Guangdong Medical University, Dongguan, 523808, China. ouyangsd@gdmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Butyrate, a major microbial metabolite derived from dietary fiber fermentation, has emerged as a key regulator in the pathogenesis and treatment of asthma. It modulates the functions of dendritic cells, macrophages, and T cells, thereby reshaping the inflammatory microenvironment. In parallel, butyrate influences the transcriptional activity of inflammation-related genes through epigenetic mechanisms such as histone acetylation, DNA demethylation, and miRNA regulation. Notably, butyrate mediates long-range immune modulation via the gut-lung axis, linking intestinal microbial homeostasis to pulmonary inflammation. This review summarizes current advances in understanding the central role of butyrate within the immune-epigenetic-gut-lung network and discusses emerging therapeutic strategies based on microbiota modulation and targeted delivery systems. Regulation of the butyrate pathway offers new insights into the complex pathogenesis of asthma and potential avenues for innovative therapeutic development.

Indexed as

AsthmaButyratesEpigenesis, GeneticLungAnimalsGastrointestinal MicrobiomeHumansButyratesAsthmaButyrateEpigeneticsGut-lung axisImmune cellsTherapeutic strategies

Identifiers

PMID41940983

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.