Evidence map›Paper›PMID 41940812›Full record

Observational studyDiabetes care2026

Hyperglycemia During Acute Pancreatitis and Progression to Early-Onset Diabetes After Recovery: Preliminary Findings From the Diabetes Related to Acute Pancreatitis and Its Mechanisms (DREAM) Study.

Kathleen M Dungan, Vernon M Chinchilli, Ariana Pichardo-Lowden, Nazia Raja-Khan, Melena D Bellin, Dhiraj Yadav, Phil A Hart, Marina Basina, James L Buxbaum, Anna Casu and 17 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Diabetes care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Kathleen M DunganDivision of Endocrinology, Diabetes & Metabolism, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.ORCID 0000-0003-1289-1595
Vernon M ChinchilliDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA.
Ariana Pichardo-LowdenDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA.
Nazia Raja-KhanDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, Penn State College of Medicine, Hershey, PA.
Melena D BellinDepartment of Pediatrics, Division of Pediatric Endocrinology, and Department of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Dhiraj YadavDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Phil A HartDivision of Gastroenterology, Hepatology, and Nutrition, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Marina BasinaDivision of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, CA.
James L BuxbaumDivision of Gastrointestinal and Liver Diseases, Department of Medicine, University of Southern California, Los Angeles, CA.
Anna CasuAdventHealth Translational Research Institute, Orlando, FL.
Carmella Evans-MolinaDepartments of Pediatrics, Medicine, Cellular & Integrative Physiology and Biochemistry & Molecular Biology, Center for Diabetes and Metabolic Diseases and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN.
Darwin L ConwellDepartment of Internal Medicine, College of Medicine at the University of Kentucky, Lexington, KY.
Evan L FogelDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN.
Chris E ForsmarkDivision of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, FL.
Mark O GoodarziDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Rita R KalyaniDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD.
Brian T LaydenDivision of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL.
Sandra M LordCenter for Interventional Immunology, Benaroya Research Institute at Virginia Mason Franciscan Health, Seattle, WA.
Georgios I PapachristouDivision of Gastroenterology, Hepatology, and Nutrition, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Walter G ParkDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA.
Richard PratleyAdventHealth Translational Research Institute, Orlando, FL.
Vikesh K SinghDivision of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, MD.
Cate SpeakeCenter for Interventional Immunology, Benaroya Research Institute at Virginia Mason Franciscan Health, Seattle, WA.
Guru TrikudanathanDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.
Maren LaughlinDivision of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Frederico G S ToledoDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0002-6570-9948
Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)*

Funding

Data Coordinating Center for the Type 1 Diabetes in Acute Pancreatitis ConsortiumU01DK127384 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Vernon M Chinchilli, Temel Tirkes · 2020 to 2026
$21.3M
Southern California Clinical Center of the Type 1 Diabetes in Acute Pancreatitis ConsortiumU01DK127403 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Mark Goodarzi, Stephen J. Pandol · 2020 to 2026
$2.5M
Mechanisms of diabetes from acute pancreatitis in African Americans and HispanicsU01DK127378 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Brian Thomas Layden, Cemal Yazici · 2020 to 2026
$2.4M
UPMC Clinical Center for the Study of Diabetes After Acute PancreatitisU01DK127377 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Frederico G. S. Toledo, Dhiraj Yadav · 2020 to 2026
$2.4M
Indiana University clinical Center for acute pancreatitis and diabetes clinical research networkU01DK127382 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina, Evan L Fogel · 2020 to 2026
$2.4M
Epidemiology and Pathophysiology of Acute Pancreatitis-related Diabetes MellitusU01DK127388 · NIDDK · OHIO STATE UNIVERSITY · PI Kathleen Marie Dungan, Philip A. Hart · 2020 to 2026
$2.4M
Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute PancreatitisU01DK127400 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Rita R Kalyani, ZHAOLI SUN · 2020 to 2026
$2.3M
University of Minnesota Clinical Center for the Study of Acute Pancreatitis and DiabetesU01DK127367 · NIDDK · UNIVERSITY OF MINNESOTA · PI Melena D. Bellin, Guru V Trikudanathan · 2020 to 2026
$2.3M
The Stanford Clinical Center for the Study of Type 1 Diabetes in Acute PancreatitisU01DK127395 · NIDDK · STANFORD UNIVERSITY · PI Marina Basina, Walter Gwang-Up Park · 2020 to 2026
$2.2M
Type 1 Diabetes in Acute Pancreatitis Consortium, Pacific Northwest Clinical Center: Immune Pathogenesis of Post-Pancreatitis T1DU01DK127404 · NIDDK · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Richard Anthony Kozarek, Cate Speake · 2020 to 2026
$2.1M
Type 1 Diabetes in Acute Pancreatitis Consortium - Clinical CentersU01DK127392 · NIDDK · UNIVERSITY OF FLORIDA · PI CHRISTOPHER E FORSMARK, STEVEN J HUGHES · 2020 to 2026
$1.9M
NIDDK NIH HHS U01 DK127367NIDDK NIH HHS U01DK127367NIDDK NIH HHS U01 DK127377NIDDK NIH HHS U01DK127377NIDDK NIH HHS U01 DK127378NIDDK NIH HHS U01DK127378NIDDK NIH HHS U01 DK127382NIDDK NIH HHS U01DK127382NIDDK NIH HHS U01 DK127384NIDDK NIH HHS U01DK127384NIDDK NIH HHS U01 DK127388NIDDK NIH HHS U01DK127388NIDDK NIH HHS U01 DK127392NIDDK NIH HHS U01DK127392NIDDK NIH HHS U01 DK127395NIDDK NIH HHS U01DK127395NIDDK NIH HHS U01 DK127400NIDDK NIH HHS U01DK127400NIDDK NIH HHS U01 DK127403NIDDK NIH HHS U01DK127403NIDDK NIH HHS U01 DK127404NIDDK NIH HHS U01DK127404
6 · The paper itself

Abstract

objectiveHyperglycemia during acute pancreatitis (HDAP) likely reflects both stress hormone responses and pancreatic islet injury, distinguishing it from typical stress-induced hyperglycemia. The aim of this study was to determine the prevalence of HDAP and its prognostic significance for early-onset diabetes following acute pancreatitis (AP). RESEARCH DESIGN AND

methodsDiabetes Related to Acute Pancreatitis and Its Mechanisms (DREAM) is a prospective multicenter study examining the development of diabetes following AP. This analysis included 395 participants without prior diabetes with an AP episode, focusing on their glucose levels during the event. Two definitions of HDAP were examined: peak glucose >140 mg/dL (HDAP140) and >200 mg/dL (HDAP200). Outpatient glycemic status after recovery (median: 111 days post-AP) was evaluated using fasting glucose, oral glucose tolerance test, and HbA1c.

resultsHDAP140 and HDAP200 were present in 37.5% and 7.1% of participants, respectively. Age, race, etiology, and AP severity were significant predictors of HDAP140. Among participants with HDAP140, 14.8% developed early-onset diabetes after AP recovery vs. 1.2% in those without (P = 0.0001). In those with HDAP200, 42.9% developed early-onset diabetes vs. 3.5% in those without (P = 0.0001). The absence of HDAP140 and HDAP200 was associated with negative predictive values of 99% and 97%, respectively, for diabetes.

conclusionsHDAP can be common in individuals without diabetes and is associated with early-onset diabetes following AP. Individuals without HDAP have a low risk of diabetes short term, while those with HDAP200 are at high risk. Monitoring glycemia during AP can identify individuals best suited for early targeted postdischarge care.

Indexed as

Diabetes MellitusHyperglycemiaPancreatitisAcute DiseaseAdultAgedBlood GlucoseFemaleHumansMaleMiddle AgedProspective StudiesBlood Glucose

Identifiers

PMID41940812
PMCPMC13191424

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.