Observational studyPulmonary medicine2026
Impact of Frailty on Prognosis and Functional Outcome in Patients With Acute Respiratory Deterioration of Interstitial Lung Disease.
Observational study in Pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Impact of Frailty on Prognosis and Functional Outcome in Patients With Acute Respiratory Deterioration of Interstitial Lung Disease.Pulmonary medicine · 2026Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty has emerged as an important prognostic factor in patients with interstitial lung disease (ILD), but its impact on hospitalized ILD patients with acute respiratory deterioration (ARD) remains unclear. The objective of this study is to investigate the association between preadmission frailty and clinical outcomes including 180-day mortality and functional decline in ILD patients hospitalized due to ARD.
methodsThis multicenter prospective study included ILD patients admitted due to ARD at five acute care hospitals in Japan. Frailty was assessed at admission using the Clinical Frailty Scale (CFS) based on patients' prehospitalization condition. The primary outcome was 180-day mortality from the day of admission. Secondary outcomes included early ambulation and functional decline at discharge. Cox regression and logistic regression analyses were used to assess the impact of frailty on outcomes.
resultsAmong 205 patients, 37 (18.0%) were classified as frail (CFS 5-9). The frail group had significantly higher 180-day mortality than the nonfrail group (p = 0.002). Frailty remained an independent predictor of 180-day mortality after multivariable adjustment (hazard ratio 2.450, 95% confidence interval [CI]1.327-4.524, p = 0.004). Nonfrailty was an independent predictor of early ambulation (odds ratio [OR] 4.820, 95% CI 1.700-13.600, p = 0.003); however, it was not a significant predictor of functional decline (OR 1.810, 95% CI 0.748-4.380, p = 0.188).
conclusionsFrailty independently predicted mortality and adverse functional outcomes in ILD patients hospitalized due to ARD. Frailty assessment on admission may help identify patients who require early and tailored multidisciplinary interventions.
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