ArticleMicrobiology spectrum2026
Nrf2 regulates angiogenesis in spinal cystic echinococcosis via RTN4.
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Spinal cystic echinococcosis (CE) is a rare but serious zoonotic disease associated with significant morbidity, disability, and mortality in endemic regions. It has the potential to cause disability or death in more than half of those affected. Due to its complex pathological features, conventional drugs and surgical interventions are often ineffective, highlighting the pressing requirement for identifying novel therapeutic targets. This study aimed to clarify the function of Nrf2, which is highly expressed, in the neovascularization linked to cystic echinococcosis of the spinal cord and to investigate its potentially relevant molecular mechanisms. Establishing a co-culture system between protoscoleces (PSCs) and human umbilical vein endothelial cells (HUVECs) with high expression of Nrf2 significantly enhanced the proliferation, migration, and angiogenesis of HUVECs. Additionally, it exhibited significant anti-angiogenic effects in a cystic IMPORTANCE: Spinal cystic echinococcosis represents a severe therapeutic challenge in endemic regions, characterized by progressive osseous destruction and high rates of recurrence following surgical intervention. The pathogenic mechanisms underpinning parasitic establishment and survival, particularly the role of host-derived angiogenesis, remain poorly elucidated, hindering the development of targeted therapies. This study identifies a critical host signaling axis, involving the transcription factor Nrf2 and its downstream target RTN4, which is exploited by
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