ArticleCancer medicine2026
Rising Risk of Subsequent Primary Cancers Among US Cancer Survivors, 2000-2021.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Rising Risk of Subsequent Primary Cancers Among US Cancer Survivors, 2000-2021.Cancer medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundAs cancer survival improves, the population at risk for subsequent primary cancers (SPCs) is growing rapidly. Yet, contemporary trends in SPC incidence remain undercharacterized, limiting the development of targeted surveillance and survivorship strategies.
objectiveTo evaluate long-term trends in SPC risk among US cancer survivors and identify high-risk subgroups by cancer type and demographic characteristics. DESIGN, SETTING, AND
participantsThis retrospective cohort study used data from 17 SEER registries and included over 6 million individuals diagnosed with an index primary cancer between 2000 and 2021. MAIN OUTCOMES AND MEASURES: Standardized incidence ratios (observed-to-expected ratios, OERs) and Cox proportional hazards models were used to assess SPC trends among male and female cancer survivors. Analyses were stratified by cancer site, latency between index and SPC, stage, age, and race/ethnicity.
resultsSPC risk increased substantially from 2000 to 2020. Among men, OERs rose from 0.95 (95% CI = 0.94, 0.97) to 1.75 (95% CI = 1.70, 1.80); among women, from 1.23 (95% CI = 1.21, 1.24) to 1.76 (95% CI = 1.70, 1.83). The highest SPC incidence occurred within 6 months of the index diagnosis. Variations were observed across demographic and cancer-related characteristics. CONCLUSIONS AND RELEVANCE: The rising burden of SPCs highlights a critical need in survivorship care. These findings support the need for updated, risk-stratified surveillance protocols and inform national cancer control strategies aimed at reducing long-term morbidity among survivors. STUDY TYPE: Cohort study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.