ArticleEpileptic disorders : international epilepsy journal with videotape2026
The second unprovoked seizure in a cohort of treated patients with a first unprovoked seizure.
Article in Epileptic disorders : international epilepsy journal with videotape, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo evaluate the rate of a second unprovoked seizure in antiseizure medications (ASMs)-treated patients following a first unprovoked seizure and to identify potential risk factors associated with its occurrence.
methodsA retrospective review of the computerized database and the medical records of all the patients who presented to our outpatient epilepsy clinic following admission and ASM initiation due to a first unprovoked seizure during a decade (2012-2021).
resultsThe study group included 60 patients aged 18-84 years (mean: 40.8 years), 35 (58.3%) men. A second unprovoked seizure occurred in 43% of the patients at last observation. Seventy-five percent of the recurrences occurred at 3 years. Patients with a second unprovoked seizure were younger (32.9 vs. 46.9 years) (p = 0.010) and more likely to be women (64% vs. 28.6%) (p = 0.009) compared to patients without recurrent seizures. SIGNIFICANCE: Women and younger patients may deserve closer monitoring following a first unprovoked seizure. Further studies are needed to assess the efficacy of specific treatment strategies among all people with a first unprovoked seizure, with emphasis on younger adults and especially women.
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