Evidence map›Paper›PMID 41940466›Full record

ArticleClinical endocrinology2026

Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non-Functioning Pituitary Adenoma.

Victor Hantelius, Gudmundur Johannsson, Sofie Jakobsson, Erik Thurin, Tobias Hallen, Thomas Skoglund, Oskar Ragnarsson

Abstract read
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In one paragraph

Article in Clinical endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Victor HanteliusDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0009-0005-6109-9678
Gudmundur JohannssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sofie JakobssonUniversity of Gothenburg Centre for Person-Centred Care (GPCC), Gothenburg, Sweden.
Erik ThurinDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Tobias HallenDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Thomas SkoglundDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Oskar RagnarssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

Health & Medical Care Committee of the Region Västra Götaland VGFOUREG-929693The ALF-agreement ALFGBG-1006371The ALF-agreement ALFGBG-719531The ALF-agreement ALFGBG-772591The ALF-agreement ALFGBG-966066The Swedish Cancer Society
6 · The paper itself

Abstract

objectiveThe effect of transsphenoidal surgery (TSS) on the hypothalamic-pituitary-gonadal (HPG) axis in patients with non-functioning pituitary adenomas (NFPA) is underexplored, especially in women. Our aim was to investigate the HPG axis function before and after TSS, its association with quality of life (QoL), and to identify factors that predict its recovery after TSS.

designThis was a prospective cohort study. PATIENTS: One hundred twenty-two consecutive patients, 73 men and 49 women, with NFPA planned for TSS. MEASUREMENTS: Endocrine function and QoL were assessed before and 12 months after TSS. Psychological well-being was evaluated using the Psychological General Well-Being index (PGWBi).

resultsBefore surgery, 50 of 73 (68%) men had hypogonadotropic hypogonadism (HH), of whom four (8%) recovered. Eight of 13 (62%) women of reproductive age had preoperative HH, of whom 5 (63%) regained regular menstrual cycles. Preoperative central hypothyroidism (p = 0.046) and male sex (p = 0.027) were predictors of persistent HH. The median total PGWBi score increased in both men and women following surgery (p < 0.001). Comparing psychological well-being within subgroups in patients with preoperative HH, categorised by sex (men or women of reproductive age) and postoperative recovery status, only women of reproductive age who recovered their HPG axis experienced improved psychological well-being.

conclusionsHH is frequent in men and women with NFPA planned for TSS. Postoperative HPG axis recovery rate is higher in women and is associated with improved QoL.

Indexed as

AdenomaHypogonadismPituitary NeoplasmsAdultAgedFemaleHumansHypothalamic-Pituitary-Gonadal AxisMaleMiddle AgedProspective StudiesQuality of Lifehypogonadotropic hypogonadismnon‐functioning pituitary adenomapituitary tumourquality of lifesurgerytranssphenoidal

Identifiers

PMID41940466
PMCPMC13532119

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