Evidence map›Paper›PMID 41940394›Full record

SynthesisPeerJ2026

Increased risk of venous thromboembolism in children and teenagers with inflammatory bowel disease: a systematic review and meta-analysis.

Yuezhong Shen, Yuyue Jiang, Yan Wang, Changqing Xu, Xi Wang, Xuqing Huang

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuezhong ShenDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Yuyue JiangDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Yan WangDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Changqing XuDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Xi WangDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Xuqing HuangDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The increased risk of venous thromboembolism (VTE) in adults with inflammatory bowel disease (IBD) is well known, but we know less about the VTE risk of IBD in children and teenagers. We evaluated the risk of VTE in children and teenagers through systematic review and meta-analysis. Methods: A systematic search was conducted in PubMed, Embase, Cochrane Library, Web of Science for studies from the establishment of these databases to February 10, 2026, to find relevant research on the risk of VTE in children and teenagers with IBD (PROSPERO, ID: CRD420251081653). Random-effects and fixed-effects models were used to estimate the relative risk (RR) and the corresponding 95% confidence interval (CI). The quality of the included studies was evaluated using the Newcastle-Ottawa Scale. Results: Seven cohort studies were included in this systematic review, involving 101,253 children and teenagers with IBD and 19,651,587 non-IBD controls. Compared with non-IBD children and teenagers, the overall RR of VTE in children and teenagers with IBD was 6.94 (95% CI [1.87-25.69], Conclusions: Children and teenagers with IBD are at a significantly increased risk of developing VTE. Therefore, VTE prevention strategies should be emphasized in this population as well as in adults.

Indexed as

Inflammatory Bowel DiseasesVenous ThromboembolismAdolescentChildHumansRisk FactorsChildrenInflammatory bowel diseaseSystematic reviewTeenagersVenous thromboembolism

Identifiers

PMID41940394
PMCPMC13050219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.