ArticlePeerJ2026
Maternal dietary vitamin A and polyunsaturated fatty acids intake and risk of preterm birth: a nested case-control study.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The impact of maternal dietary intake of vitamin A and polyunsaturated fatty acids (PUFAs) on preterm birth (PTB) risk remains uncertain. This study aims to investigate the effects of preconception and pregnancy dietary intake of these nutrients on PTB risk and to examine potential interactions between vitamin A and PUFAs. Methods: The study subjects were pregnant women who registered at the Perinatal Medicine Center of Gansu Provincial Maternity and Child-care Hospital between March 2018 and March 2019 and whose birth outcomes could be followed up. Following ethics approval and consent, one-on-one pregnancy diet surveys established a total dietary intake database for statistical analysis. PTB was used as the outcome variable, and intake levels of different substances during pregnancy were used as independent variables. Logistic regression models were employed to calculate odds ratios (OR) and their 95% confidence intervals (CI) to analyze the impact of various substance intake levels on PTB. Results: A total of 8,897 pregnant women were enrolled in this study, comprising 880 cases and 8,017 controls. Multivariate logistic regression analysis indicated that when dietary intake of vitamin A and PUFAs levels w as too low in the third trimester, the risk of PTB would be significantly increased. The specific results were (OR = 1.440, 95% CI [1.221-1.697]) and (OR = 1.319, 95% CI [1.113-1.563]), respectively. Similar conclusions were drawn in the gestational weeks subgroup. In addition, a U-shaped association was found in the third trimester of pregnancy between the intake level of dietary PUFAs and the risk of PTB, meaning that both excessive and insufficient intake increase the risk of PTB. Interaction analysis revealed that dietary vitamin A and PUFAs intake had a multiplicative interaction effect on the risk of PTB during preconception and pregnancy. Conclusion: An increased risk of PTB is associated with low intake of vitamin A and PUFAs both pre-conception and during pregnancy. Furthermore, a nonlinear relationship between intake levels and PTB risk was observed (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.