ArticleJournal of conservative dentistry and endodontics2026
Two-dimensional and three-dimensional evaluation of bone regeneration using platelet-rich fibrin versus bone putty in large periapical lesions after endodontic surgery: A randomized clinical trial.
Article in Journal of conservative dentistry and endodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clinical Outcomes of Platelet-Rich Fibrin in Endodontic Microsurgery: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: The aim of this study was to perform a two-dimensional (2D) and three-dimensional (3D) comparative evaluation of bone regeneration using autologous platelet-rich fibrin (PRF) versus calcium phosphosilicate-based bone putty in large periapical lesions before and after endodontic surgery. Materials and Methods: Fifty patients with a history of dental trauma and periapical pathology involving the maxillary and mandibular anterior and premolar tooth regions were randomly allocated into two groups, with 25 patients in each group. All patients underwent endodontic surgery following root canal treatment. Bony defects were managed with autologous PRF in Group I and bone putty in Group II. After a 1-year follow-up period, 2D healing was assessed using intraoral periapical radiographs (IOPARs), and area calculation was performed using ImageJ software. 3D healing was evaluated using cone-beam computed tomography (CBCT), and volumetric analysis was conducted using ITK-SNAP software. Results: Patients in Group II exhibited a significantly greater reduction in lesion volume (95.017% ±5.809%) and area (98.376% ± 2.916%) compared to those in Group I (volume reduction: 72.449% ± 14.264% and area reduction: 87.868% ± 11.048%). Bone healing assessed through CBCT and volumetric analysis using ITK-SNAP (83.733 ± 15.668%) was found to be more accurate than 2D area evaluation (93.122 ± 9.598) using IOPAR. Conclusion: Calcium phosphosilicate-based bone putty demonstrated significantly faster bone regeneration than PRF. CBCT-based volumetric assessment (3D) provides a more objective and accurate evaluation of bone healing than conventional IOPAR-based area assessment (2D) and may serve as a valuable tool for assessing treatment outcomes in complex endodontic surgeries.
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Registered trials
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