Evidence map›Paper›PMID 41940351›Full record

ArticleiScience2026

Immune hub genes and a proof-of-concept prognostic signature in EBV-associated gastric carcinoma.

Rui-Zhen Huo, Ri-Hong Yang, Ri-Hua Zeng, Zi-Cen Fang, Bin Li, Yu-Hang Pan, Jin-Rui Guo, Yan-Xian Guan, Chun-Kui Shao, Dan-Ni Yu and 4 more

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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rui-Zhen HuoDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Ri-Hong YangDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Ri-Hua ZengDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Zi-Cen FangNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Bin LiDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Yu-Hang PanDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Jin-Rui GuoDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Yan-Xian GuanDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Chun-Kui ShaoDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Dan-Ni YuDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Si-Hong LiangDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Yi-Ting ShaoDepartment of Stomatology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Yu DuDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Jian-Ning ChenDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epstein-Barr virus-associated gastric carcinoma (EBVaGC) represents a distinct molecular subtype with unique immune characteristics but lacks subtype-specific prognostic tools for clinical management. We developed an immune-based prognostic signature by integrating transcriptomic profiling, immunohistochemical validation, and functional assays. PTPRC (CD45) and ITGB2 (CD18) were identified as central immune regulators with strong correlation (r = 0.78,

Indexed as

Health informaticsHealth sciencesInternal medicineMedical specialtyMedicineOncology

Identifiers

PMID41940351
PMCPMC13049670

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.