Evidence map›Paper›PMID 41940304›Full record

ReviewFrontiers in neurology

Comprehensive, multidisciplinary care for fragile X-associated tremor/ataxia syndrome.

James A Bourgeois, Andrea Schneider, Jessica Klusek, Thomas R Christensen, Ellie Levin, Kendall Gardner, Ariel A Jacobi, Randi J Hagerman

Abstract readReview
In one paragraph

Review in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cognitive-behavioral phenotypes inFrontiers in molecular neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

James A BourgeoisUC Davis Health Department of Psychiatry and Behavioral Sciences, School of Medicine, Sacramento, CA, United States.
Andrea SchneiderUC Davis Health MIND Institute and Department of Pediatrics, School of Medicine, Sacramento, CA, United States.
Jessica KlusekDepartment of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States.
Thomas R ChristensenDepartment of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States.
Ellie LevinUC Davis, Davis, CA, United States.
Kendall GardnerTouro University College of Osteopathic Medicine, Vallejo, CA, United States.
Ariel A JacobiUC Davis School of Medicine, Sacramento, CA, United States.
Randi J HagermanUC Davis Health MIND Institute and Department of Pediatrics, School of Medicine, Sacramento, CA, United States.

Funding

GENOTYPE/PHENOTYPE RELATIONSHIPS IN FRAGILE X FAMILIESR01HD036071 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI PAUL J HAGERMAN, RANDI J. HAGERMAN · 1998 to 2026
$13.8M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
Aging Symptom Trajectories in Mother Carriers of the FMR1 PremutationR01AG073374 · NIA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Jessica Klusek · 2022 to 2026
$3.4M
NIA NIH HHS R01 AG073374NICHD NIH HHS P50 HD103526NICHD NIH HHS R01 HD036071
6 · The paper itself

Abstract

Objective: The authors reviewed the pathophysiology, clinical genetics, phenotype, and comprehensive clinical management of Fragile X-associated Tremor/Ataxia Syndrome (FXTAS), a neurodegenerative disorder affecting Participants: A multispecialty and multidisciplinary team of authors with backgrounds in psychiatry, pediatrics, clinical psychology, speech and language pathology, and neurosciences. Evidence: Review of English language sources on the clinical phenomenology, genetics, pathophysiology, and clinical management of FXTAS from 2001 (the original report) through 2025, with emphasis on the general medical, psychiatric, and neurological features of FXTAS and its multispecialty and multidisciplinary clinical management. Consensus process: All authors contributed to the review of the literature. Major components of the manuscript were drafted by clinicians with clinical experience in the specific areas of management. Conclusion: Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder affecting

Indexed as

fragile X-associated tremor/ataxia syndromefragile X syndromefronto-subcortical dementia/major neurocognitive disorderFXANDFXPOIFXTAS

Identifiers

PMID41940304
PMCPMC13043407

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.