ReviewCancer management and research2026
Prognostic Significance of Sarcopenia in Colorectal Cancer: A Review of Clinical Evidence.
Review in Cancer management and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Sarcopenia in breast cancer: prognostic values and emerging therapeutic strategies.Frontiers in surgery · 2026Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colorectal cancer (CRC) is one of the most common and deadly malignancies worldwide. Sarcopenia, defined as a progressive loss of skeletal muscle mass and function, has recently been recognized as an important prognostic factor in CRC, influencing both postoperative complications and long-term survival. Methods: We conducted a descriptive review of 18 clinical studies investigating the association between sarcopenia and CRC across stages I-IV. Sarcopenia was primarily assessed using computed tomography-derived skeletal muscle index (SMI) or psoas index (PI) at the lumbar vertebrae (L3/L4), with some studies additionally incorporating muscle strength and performance. Results: The prevalence of sarcopenia among CRC patients ranged from 12% to 60%. Most studies reported higher risks of postoperative complications in sarcopenic patients. For instance, Peng et al demonstrated an increased risk of complications in stage IV CRC patients with sarcopenia (OR: 3.12, 95% CI: 1.14-8.49). Regarding survival, sarcopenia was consistently associated with worse overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS). Brown et al (2018) showed that deterioration in muscle mass and radiodensity significantly predicted poorer OS in 1,924 stage I-III CRC patients (HR: 2.15, 95% CI: 1.59-2.92). However, several studies reported no significant associations. Conclusion: Sarcopenia is prevalent in CRC patients and strongly correlates with both short-term surgical outcomes and long-term prognosis. However, current evidence is mainly derived from heterogeneous observational studies, and further prospective studies are needed before sarcopenia assessment can be translated into routine clinical practice.
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