ArticleBrain communications2026
Network-specific enhancement of global blood-oxygen-level-dependent signals and CSF coupling after language therapy in post-stroke aphasia.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Emerging evidence indicates that stroke may impair glymphatic function by disrupting cerebrospinal fluid clearance. The coupling between global blood-oxygen-level-dependent signals and cerebrospinal fluid flow has been proposed as a non-invasive biomarker of glymphatic activity. However, it remains unclear whether this coupling can be modulated through rehabilitation. This study investigated whether language therapy in patients with post-stroke aphasia enhances global blood-oxygen-level-dependent- cerebrospinal fluid coupling, thereby reflecting potential restoration of fluid-brain interaction. This longitudinal observational study was conducted at a single centre and included 20 patients with post-stroke aphasia and 35 age- and sex-balanced healthy controls. All participants underwent MRI scanning, including resting-state blood-oxygen-level-dependent and structural imaging. Among the post-stroke aphasia group, 14 patients completed both pre- and post-treatment assessments after undergoing a standardized 4-week speech-language therapy programme. The Western Aphasia Battery was used to quantify language deficits and monitor treatment-related changes. Global blood-oxygen-level-dependent-cerebrospinal fluid coupling was quantified using cross-correlation analysis across the whole brain and four predefined language-related resting-state networks. At baseline, patients exhibited significantly reduced global blood-oxygen-level-dependent-cerebrospinal fluid coupling compared to healthy controls (
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