ArticleBrain communications2026
Association of structural brain changes with cognitive deficits and fatigue in patients with post-COVID-19 condition.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
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Abstract
Cognitive impairment and fatigue are frequent symptoms in patients with post-COVID-19 condition. However, cognitive issues are often only self-reported and not compared to well-matched control groups. Furthermore, structural brain changes, underlying cognitive impairment and fatigue in post-COVID-19 condition are still not fully understood. To assess cognitive deficits, fatigue, neuropsychiatric symptoms and quality of life in patients with post-COVID-19 condition, determine changes in brain volumes, cortical thickness and regional shape complexity and assess correlations of imaging measures with clinical symptoms, 49 patients with post-COVID-19 condition (80% female) with a confirmed SARS-CoV-2 infection at least 3 months prior to testing and new onset of cognitive complaints and 48 healthy controls matched for sex, age and education level underwent comprehensive neuropsychological testing, MRI-based volumetric analyses, and fractal dimensionality analysis to evaluate structural brain complexity. Neuropsychiatric symptoms and quality of life were assessed using questionnaires. Patients with post-COVID-19 condition exhibited significant deficits of attention, executive functions, phonemic and semantic fluency, verbal learning and episodic and visuospatial memory (all
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